Detailed information of TA system TA144908

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2144172..2145721
• Replicon: chromosome
• Accession: NZ_CP046752
• Organism: Photobacterium damselae strain 9046-81

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GPX90_RS14930
• Protein ID: WP_158135733.1
• Coordinates: 2144172..2145473 (-)
• Length: 434 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GPX90_RS14935
• Protein ID: WP_036764367.1
• Coordinates: 2145473..2145721 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPX90_RS14915	2139782..2140828	+	1047	WP_069530874.1	putrescine carbamoyltransferase	-
GPX90_RS14920	2140879..2143293	-	2415	WP_158135729.1	DEAD/DEAH box helicase family protein	-
GPX90_RS14925	2143295..2143870	-	576	WP_158135731.1	class I SAM-dependent methyltransferase	-
GPX90_RS14930	2144172..2145473	-	1302	WP_158135733.1	type II toxin-antitoxin system HipA family toxin	Toxin
GPX90_RS14935	2145473..2145721	-	249	WP_036764367.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
GPX90_RS14940	2146272..2146745	-	474	WP_044176532.1	hypothetical protein	-
GPX90_RS14945	2147062..2150274	+	3213	WP_158135735.1	RNA-directed DNA polymerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-64)

Sequences

Toxin

Protein

• Length: 434 a.a.
• Molecular weight: 48672.31 Da
• Isoelectric Point: 7.3939

>T144908 WP_158135733.1 NZ_CP046752:c2145473-2144172 [Photobacterium damselae]
MQKLIAYMNGELVGTLEKHKNGAHTFQYDKNWLTNAVTRPLSLSLKLQLPAITSDAVINYFDNLLPDSPQVRDRIVARYK
ASSKQPFDLLKEIGKDSVGAIALLPPDLPYKKEPLSYEVLDDKKLETVLSAYKSDIPLGMLEEEEDFRISVAGAQEKTAL
LFVDEQWCIPKGNTPTTHIIKLPIGEIQQANATLDLKDSVENEYLCIELARALGFAVPNVNIIQTDNIKALAVERFDRRW
TKDRAGLLRLPQEDICQVFGMPSSIKYESQGGPGIAQIMELLMGSSNALEDRYNFMRFQVFQWLIGATDGHAKNFSIYID
KGGSYRLTPFYDILSAYPLLGGKGLNIRKLKLAMGLKATKGKKYEISKILPRHFLDTAKDVNFNQDTMQEIIDEMKDALP
KAMLQVSATLPKGFPEHIVSSIFENTQKIVKKI

Nucleotide

• Length: 1302 bp

>T144908 NZ_CP062245:c3693446-3693339 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9351.69 Da
• Isoelectric Point: 6.2564

>AT144908 WP_036764367.1 NZ_CP046752:c2145721-2145473 [Photobacterium damselae]
MIYSPKQLADMMLLIRQKNGWTQSELAKKVGIKQATISNFENNPNKTTLSTFFKLVQAMDLTLSIQEKSQVASLNENDDE
SW

Nucleotide

• Length: 249 bp

>AT144908 NZ_CP062245:3693495-3693561 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC