Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-Phd |
| Location | 85500..86047 | Replicon | chromosome |
| Accession | NZ_CP046750 | ||
| Organism | Vibrio cholerae strain 2015V-1118 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | GPX93_RS14195 | Protein ID | WP_000818171.1 |
| Coordinates | 85500..85802 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KM93 |
| Locus tag | GPX93_RS14200 | Protein ID | WP_000861987.1 |
| Coordinates | 85790..86047 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPX93_RS14145 | 80539..81027 | - | 489 | WP_123161896.1 | hypothetical protein | - |
| GPX93_RS14150 | 81055..81165 | - | 111 | WP_080478889.1 | DUF3265 domain-containing protein | - |
| GPX93_RS14155 | 81639..82367 | - | 729 | WP_184482346.1 | hypothetical protein | - |
| GPX93_RS18755 | 82560..82731 | - | 172 | Protein_134 | DUF645 family protein | - |
| GPX93_RS14170 | 83036..83461 | - | 426 | WP_123161898.1 | GNAT family N-acetyltransferase | - |
| GPX93_RS14175 | 83594..84100 | - | 507 | WP_045595225.1 | DUF2199 domain-containing protein | - |
| GPX93_RS14180 | 84239..84754 | - | 516 | WP_123161899.1 | MazG-related protein | - |
| GPX93_RS14190 | 84884..85297 | - | 414 | WP_000049425.1 | VOC family protein | - |
| GPX93_RS14195 | 85500..85802 | - | 303 | WP_000818171.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPX93_RS14200 | 85790..86047 | - | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GPX93_RS14205 | 86258..86755 | - | 498 | WP_123161900.1 | hypothetical protein | - |
| GPX93_RS14210 | 86974..87138 | - | 165 | WP_080476722.1 | DUF645 family protein | - |
| GPX93_RS18760 | 87182..87373 | - | 192 | Protein_143 | hypothetical protein | - |
| GPX93_RS14215 | 87518..87970 | + | 453 | WP_000024294.1 | DUF2384 domain-containing protein | - |
| GPX93_RS14220 | 87970..88440 | + | 471 | WP_000784954.1 | RES family NAD+ phosphorylase | - |
| GPX93_RS14230 | 88571..89056 | - | 486 | WP_123161901.1 | hypothetical protein | - |
| GPX93_RS14235 | 89606..90406 | - | 801 | WP_123161852.1 | PhzF family phenazine biosynthesis protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA | 2..1102730 | 1102728 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11709.57 Da Isoelectric Point: 4.8838
>T144906 WP_000818171.1 NZ_CP046750:c85802-85500 [Vibrio cholerae]
MAEIVWTEPALSDLNDIAEYIALENVVAAKQLVQTIFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDANV
RILFVMRAERDLRRLMLTKQ
MAEIVWTEPALSDLNDIAEYIALENVVAAKQLVQTIFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDANV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T144906 NZ_CP062245:c3227813-3227499 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT144906 WP_000861987.1 NZ_CP046750:c86047-85790 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT144906 NZ_CP062245:c3227502-3227086 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|