Detailed information of TA system TA144905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 51456..52003
• Replicon: chromosome
• Accession: NZ_CP046750
• Organism: Vibrio cholerae strain 2015V-1118

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPX93_RS13900
• Protein ID: WP_071187828.1
• Coordinates: 51456..51758 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GPX93_RS13905
• Protein ID: WP_055031549.1
• Coordinates: 51746..52003 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPX93_RS13870	46946..47332	-	387	WP_184482338.1	VOC family protein	-
GPX93_RS13875	47491..48039	-	549	WP_123161873.1	hypothetical protein	-
GPX93_RS13880	49190..49360	-	171	Protein_82	DUF645 family protein	-
GPX93_RS13885	49554..49643	-	90	WP_123162256.1	DUF3265 domain-containing protein	-
GPX93_RS13890	49665..50453	-	789	WP_071180561.1	hypothetical protein	-
GPX93_RS13895	50625..51299	-	675	WP_184482514.1	hypothetical protein	-
GPX93_RS13900	51456..51758	-	303	WP_071187828.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPX93_RS13905	51746..52003	-	258	WP_055031549.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPX93_RS13910	52201..52572	-	372	WP_184482340.1	DUF4144 domain-containing protein	-
GPX93_RS13915	52671..53186	-	516	WP_001894921.1	lipocalin family protein	-
GPX93_RS13920	53334..54089	-	756	WP_123161878.1	hypothetical protein	-
GPX93_RS13925	54179..54901	-	723	WP_005516510.1	hypothetical protein	-
GPX93_RS13930	55076..55465	-	390	WP_055032899.1	VOC family protein	-
GPX93_RS13945	55939..56094	-	156	WP_123162257.1	DUF3265 domain-containing protein	-
GPX93_RS13950	56066..56605	-	540	WP_123161881.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA	2..1102730	1102728

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11694.60 Da
• Isoelectric Point: 5.8741

>T144905 WP_071187828.1 NZ_CP046750:c51758-51456 [Vibrio cholerae]
MAEIVWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRIPPELKHLNYREVVVNPCRVFYKYDDANV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T144905 NZ_CP062245:c3161902-3161606 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9619.14 Da
• Isoelectric Point: 7.3176

>AT144905 WP_055031549.1 NZ_CP046750:c52003-51746 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT144905 NZ_CP062245:c3161604-3161209 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA