Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DhiAT/- |
| Location | 42832..43616 | Replicon | chromosome |
| Accession | NZ_CP046750 | ||
| Organism | Vibrio cholerae strain 2015V-1118 | ||
Toxin (Protein)
| Gene name | dhiT | Uniprot ID | A0A086SLD6 |
| Locus tag | GPX93_RS13850 | Protein ID | WP_001114075.1 |
| Coordinates | 43347..43616 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | dhiA | Uniprot ID | Q9KM84 |
| Locus tag | GPX93_RS13845 | Protein ID | WP_000921691.1 |
| Coordinates | 42832..43353 (-) | Length | 174 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPX93_RS13810 | 38295..38939 | - | 645 | Protein_68 | IS5-like element ISVch8 family transposase | - |
| GPX93_RS13815 | 39030..39989 | + | 960 | WP_113592640.1 | IS30 family transposase | - |
| GPX93_RS13820 | 40017..40295 | - | 279 | Protein_70 | transposase | - |
| GPX93_RS13825 | 40422..41408 | + | 987 | WP_123161869.1 | sulfate ABC transporter substrate-binding protein | - |
| GPX93_RS13830 | 41602..41997 | - | 396 | WP_071196489.1 | DUF3465 domain-containing protein | - |
| GPX93_RS13835 | 42043..42159 | - | 117 | WP_123162255.1 | DUF3265 domain-containing protein | - |
| GPX93_RS13840 | 42156..42635 | - | 480 | WP_123161870.1 | lecithin retinol acyltransferase family protein | - |
| GPX93_RS13845 | 42832..43353 | - | 522 | WP_000921691.1 | DUF2442 domain-containing protein | Antitoxin |
| GPX93_RS13850 | 43347..43616 | - | 270 | WP_001114075.1 | DUF4160 domain-containing protein | Toxin |
| GPX93_RS13855 | 43906..44865 | + | 960 | WP_113592640.1 | IS30 family transposase | - |
| GPX93_RS13860 | 44896..45705 | - | 810 | WP_123161871.1 | hypothetical protein | - |
| GPX93_RS13865 | 45964..46923 | + | 960 | WP_113592640.1 | IS30 family transposase | - |
| GPX93_RS13870 | 46946..47332 | - | 387 | WP_184482338.1 | VOC family protein | - |
| GPX93_RS13875 | 47491..48039 | - | 549 | WP_123161873.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 38295..38966 | 671 | |
| - | inside | Integron | - | hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA | 2..1102730 | 1102728 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10310.94 Da Isoelectric Point: 6.6303
>T144904 WP_001114075.1 NZ_CP046750:c43616-43347 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC
Download Length: 270 bp
>T144904 NZ_CP062245:c3034181-3033774 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 174 a.a. Molecular weight: 19409.01 Da Isoelectric Point: 6.7342
>AT144904 WP_000921691.1 NZ_CP046750:c43353-42832 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI
Download Length: 522 bp
>AT144904 NZ_CP062245:c3034428-3034162 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A086SLD6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q9KM84 |