Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 42832..43616 Replicon chromosome
Accession NZ_CP046750
Organism Vibrio cholerae strain 2015V-1118

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag GPX93_RS13850 Protein ID WP_001114075.1
Coordinates 43347..43616 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag GPX93_RS13845 Protein ID WP_000921691.1
Coordinates 42832..43353 (-) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX93_RS13810 38295..38939 - 645 Protein_68 IS5-like element ISVch8 family transposase -
GPX93_RS13815 39030..39989 + 960 WP_113592640.1 IS30 family transposase -
GPX93_RS13820 40017..40295 - 279 Protein_70 transposase -
GPX93_RS13825 40422..41408 + 987 WP_123161869.1 sulfate ABC transporter substrate-binding protein -
GPX93_RS13830 41602..41997 - 396 WP_071196489.1 DUF3465 domain-containing protein -
GPX93_RS13835 42043..42159 - 117 WP_123162255.1 DUF3265 domain-containing protein -
GPX93_RS13840 42156..42635 - 480 WP_123161870.1 lecithin retinol acyltransferase family protein -
GPX93_RS13845 42832..43353 - 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
GPX93_RS13850 43347..43616 - 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
GPX93_RS13855 43906..44865 + 960 WP_113592640.1 IS30 family transposase -
GPX93_RS13860 44896..45705 - 810 WP_123161871.1 hypothetical protein -
GPX93_RS13865 45964..46923 + 960 WP_113592640.1 IS30 family transposase -
GPX93_RS13870 46946..47332 - 387 WP_184482338.1 VOC family protein -
GPX93_RS13875 47491..48039 - 549 WP_123161873.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 38295..38966 671
- inside Integron - hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA 2..1102730 1102728


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T144904 WP_001114075.1 NZ_CP046750:c43616-43347 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T144904 NZ_CP062245:c3034181-3033774 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT144904 WP_000921691.1 NZ_CP046750:c43353-42832 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT144904 NZ_CP062245:c3034428-3034162 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References