Detailed information of TA system TA144903

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-Phd
• Location: 18516..19094
• Replicon: chromosome
• Accession: NZ_CP046750
• Organism: Vibrio cholerae strain 2015V-1118

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GPX93_RS13625
• Protein ID: WP_184482332.1
• Coordinates: 18777..19094 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: GPX93_RS13620
• Protein ID: WP_123161849.1
• Coordinates: 18516..18758 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPX93_RS13570	13921..14193	+	273	WP_000246254.1	DUF1778 domain-containing protein	-
GPX93_RS13575	14190..14687	+	498	WP_000982260.1	GNAT family N-acetyltransferase	-
GPX93_RS13585	14903..15145	+	243	WP_001107719.1	type II toxin-antitoxin system ParD family antitoxin	-
GPX93_RS13590	15142..15441	+	300	WP_000802136.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GPX93_RS13595	15675..15918	+	244	Protein_29	RNA-binding protein	-
GPX93_RS13605	16201..16482	-	282	WP_123161847.1	DUF1289 domain-containing protein	-
GPX93_RS13610	16716..17702	+	987	WP_123161848.1	sulfate ABC transporter substrate-binding protein	-
GPX93_RS13615	17945..18124	-	180	Protein_32	DUF645 family protein	-
GPX93_RS13620	18516..18758	+	243	WP_123161849.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPX93_RS13625	18777..19094	+	318	WP_184482332.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPX93_RS13630	19370..19591	-	222	WP_123161851.1	DUF3709 domain-containing protein	-
GPX93_RS13635	19612..19773	-	162	Protein_36	hypothetical protein	-
GPX93_RS13640	19880..20599	-	720	WP_134818271.1	hypothetical protein	-
GPX93_RS13645	20800..21741	-	942	WP_114732559.1	hypothetical protein	-
GPX93_RS13650	21881..22681	-	801	WP_123161852.1	PhzF family phenazine biosynthesis protein	-
GPX93_RS13655	22901..23072	-	172	Protein_40	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA	2..1102730	1102728

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-59)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12189.00 Da
• Isoelectric Point: 9.7495

>T144903 WP_184482332.1 NZ_CP046750:18777-19094 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFTEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Nucleotide

• Length: 318 bp

>T144903 NZ_CP062245:c2904449-2904114 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8947.28 Da
• Isoelectric Point: 5.6618

>AT144903 WP_123161849.1 NZ_CP046750:18516-18758 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDCGKTVDGAAFLNTL

Nucleotide

• Length: 243 bp

>AT144903 NZ_CP062245:c2904697-2904449 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA