Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 14903..15441 | Replicon | chromosome |
| Accession | NZ_CP046750 | ||
| Organism | Vibrio cholerae strain 2015V-1118 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q9KMJ0 |
| Locus tag | GPX93_RS13590 | Protein ID | WP_000802136.1 |
| Coordinates | 15142..15441 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P58093 |
| Locus tag | GPX93_RS13585 | Protein ID | WP_001107719.1 |
| Coordinates | 14903..15145 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPX93_RS13540 | 10046..10708 | - | 663 | WP_123161845.1 | Vat family streptogramin A O-acetyltransferase | - |
| GPX93_RS13545 | 10912..11364 | + | 453 | WP_000024294.1 | DUF2384 domain-containing protein | - |
| GPX93_RS13550 | 11364..11834 | + | 471 | WP_000784954.1 | RES family NAD+ phosphorylase | - |
| GPX93_RS13555 | 11983..12501 | - | 519 | WP_123162254.1 | DUF2807 domain-containing protein | - |
| GPX93_RS13560 | 12816..12995 | - | 180 | WP_123161846.1 | DUF645 family protein | - |
| GPX93_RS18725 | 13352..13522 | - | 171 | WP_000483444.1 | DUF645 family protein | - |
| GPX93_RS13570 | 13921..14193 | + | 273 | WP_000246254.1 | DUF1778 domain-containing protein | - |
| GPX93_RS13575 | 14190..14687 | + | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| GPX93_RS13585 | 14903..15145 | + | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| GPX93_RS13590 | 15142..15441 | + | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPX93_RS13595 | 15675..15918 | + | 244 | Protein_29 | RNA-binding protein | - |
| GPX93_RS13605 | 16201..16482 | - | 282 | WP_123161847.1 | DUF1289 domain-containing protein | - |
| GPX93_RS13610 | 16716..17702 | + | 987 | WP_123161848.1 | sulfate ABC transporter substrate-binding protein | - |
| GPX93_RS13615 | 17945..18124 | - | 180 | Protein_32 | DUF645 family protein | - |
| GPX93_RS13620 | 18516..18758 | + | 243 | WP_123161849.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GPX93_RS13625 | 18777..19094 | + | 318 | WP_184482332.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPX93_RS13630 | 19370..19591 | - | 222 | WP_123161851.1 | DUF3709 domain-containing protein | - |
| GPX93_RS13635 | 19612..19773 | - | 162 | Protein_36 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA | 2..1102730 | 1102728 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11589.29 Da Isoelectric Point: 9.9232
>T144902 WP_000802136.1 NZ_CP046750:15142-15441 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T144902 NZ_CP062245:2770811-2771140 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8964.84 Da Isoelectric Point: 4.1677
>AT144902 WP_001107719.1 NZ_CP046750:14903-15145 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT144902 NZ_CP062245:2770473-2770790 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7R5A |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7R5A | |
| PDB | 7B22 | |
| AlphaFold DB | A0A151JFU4 |