Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 13921..14687 Replicon chromosome
Accession NZ_CP046750
Organism Vibrio cholerae strain 2015V-1118

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag GPX93_RS13575 Protein ID WP_000982260.1
Coordinates 14190..14687 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GPX93_RS13570 Protein ID WP_000246254.1
Coordinates 13921..14193 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX93_RS13525 8961..9278 + 318 WP_123161843.1 CcdB family protein -
GPX93_RS13535 9396..9911 - 516 WP_000343786.1 GNAT family N-acetyltransferase -
GPX93_RS13540 10046..10708 - 663 WP_123161845.1 Vat family streptogramin A O-acetyltransferase -
GPX93_RS13545 10912..11364 + 453 WP_000024294.1 DUF2384 domain-containing protein -
GPX93_RS13550 11364..11834 + 471 WP_000784954.1 RES family NAD+ phosphorylase -
GPX93_RS13555 11983..12501 - 519 WP_123162254.1 DUF2807 domain-containing protein -
GPX93_RS13560 12816..12995 - 180 WP_123161846.1 DUF645 family protein -
GPX93_RS18725 13352..13522 - 171 WP_000483444.1 DUF645 family protein -
GPX93_RS13570 13921..14193 + 273 WP_000246254.1 DUF1778 domain-containing protein Antitoxin
GPX93_RS13575 14190..14687 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
GPX93_RS13585 14903..15145 + 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin -
GPX93_RS13590 15142..15441 + 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPX93_RS13595 15675..15918 + 244 Protein_29 RNA-binding protein -
GPX93_RS13605 16201..16482 - 282 WP_123161847.1 DUF1289 domain-containing protein -
GPX93_RS13610 16716..17702 + 987 WP_123161848.1 sulfate ABC transporter substrate-binding protein -
GPX93_RS13615 17945..18124 - 180 Protein_32 DUF645 family protein -
GPX93_RS13620 18516..18758 + 243 WP_123161849.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GPX93_RS13625 18777..19094 + 318 WP_184482332.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPX93_RS13630 19370..19591 - 222 WP_123161851.1 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA 2..1102730 1102728


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-89)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T144901 WP_000982260.1 NZ_CP046750:14190-14687 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T144901 NZ_CP062245:2759276-2760349 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9685.19 Da        Isoelectric Point: 6.2988

>AT144901 WP_000246254.1 NZ_CP046750:13921-14193 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT144901 NZ_CP062245:2760342-2760713 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure

References