Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 662502..663030 | Replicon | chromosome |
| Accession | NZ_CP046748 | ||
| Organism | Vibrio cholerae strain 3541-04 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | H9L4R3 |
| Locus tag | GPY00_RS17370 | Protein ID | WP_000221352.1 |
| Coordinates | 662740..663030 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | H9L4T4 |
| Locus tag | GPY00_RS17365 | Protein ID | WP_000213183.1 |
| Coordinates | 662502..662750 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY00_RS17320 | 657896..658075 | - | 180 | WP_044128174.1 | DUF645 family protein | - |
| GPY00_RS17325 | 658390..659028 | - | 639 | WP_019829928.1 | hypothetical protein | - |
| GPY00_RS17330 | 659164..659742 | - | 579 | WP_001020574.1 | DJ-1/PfpI family protein | - |
| GPY00_RS17335 | 660074..660247 | - | 174 | WP_080285841.1 | DUF3709 domain-containing protein | - |
| GPY00_RS17340 | 660713..660865 | - | 153 | WP_199252431.1 | DUF3709 domain-containing protein | - |
| GPY00_RS17345 | 661212..661394 | - | 183 | WP_199252432.1 | DUF645 family protein | - |
| GPY00_RS17350 | 661578..661721 | - | 144 | WP_199252451.1 | DUF3265 domain-containing protein | - |
| GPY00_RS17355 | 661691..662092 | - | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| GPY00_RS17360 | 662092..662262 | - | 171 | WP_001080654.1 | hypothetical protein | - |
| GPY00_RS17365 | 662502..662750 | + | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GPY00_RS17370 | 662740..663030 | + | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPY00_RS17375 | 663048..663158 | - | 111 | Protein_622 | DUF3265 domain-containing protein | - |
| GPY00_RS17380 | 663155..663913 | - | 759 | WP_055050422.1 | hypothetical protein | - |
| GPY00_RS17385 | 664059..664415 | - | 357 | WP_033838071.1 | hypothetical protein | - |
| GPY00_RS17390 | 664573..665220 | - | 648 | WP_044128203.1 | glutathione S-transferase family protein | - |
| GPY00_RS17395 | 665398..665640 | - | 243 | WP_053034790.1 | hypothetical protein | - |
| GPY00_RS17405 | 665840..666580 | - | 741 | WP_161779866.1 | PhzF family phenazine biosynthesis protein | - |
| GPY00_RS17410 | 666745..667383 | - | 639 | WP_002051085.1 | HD domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 597132..672561 | 75429 | |
| - | inside | Integron | - | - | 597132..668045 | 70913 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11247.23 Da Isoelectric Point: 10.4678
>T144898 WP_000221352.1 NZ_CP046748:662740-663030 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
Download Length: 291 bp
>T144898 NZ_CP062245:2071049-2071423 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8937.28 Da Isoelectric Point: 4.1079
>AT144898 WP_000213183.1 NZ_CP046748:662502-662750 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
Download Length: 249 bp
>AT144898 NZ_CP062245:2070592-2070960 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | H9L4R3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A366A3W8 |