Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 532230..534055 Replicon chromosome
Accession NZ_CP046747
Organism Vibrio cholerae strain 3541-04

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GPY00_RS02450 Protein ID WP_032472260.1
Coordinates 532230..533591 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GPY00_RS02455 Protein ID WP_044127591.1
Coordinates 533588..534055 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY00_RS02415 527270..527698 + 429 WP_044127594.1 DUF2787 domain-containing protein -
GPY00_RS02420 527749..528195 + 447 WP_044127593.1 DUF2787 domain-containing protein -
GPY00_RS02425 528298..528825 + 528 WP_019830042.1 Flp pilus assembly complex ATPase component TadA -
GPY00_RS02430 529316..529957 - 642 WP_044127592.1 inovirus Gp2 family protein -
GPY00_RS02435 531137..531316 + 180 WP_044127623.1 hypothetical protein -
GPY00_RS02440 531396..531596 - 201 WP_019830047.1 AlpA family transcriptional regulator -
GPY00_RS02450 532230..533591 + 1362 WP_032472260.1 type II toxin-antitoxin system HipA family toxin Toxin
GPY00_RS02455 533588..534055 + 468 WP_044127591.1 helix-turn-helix domain-containing protein Antitoxin
GPY00_RS02460 534483..535061 + 579 WP_000109982.1 class I SAM-dependent methyltransferase -
GPY00_RS02465 535065..537980 + 2916 WP_199252409.1 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - acfD / acfD / acfA / acfC / acfB / tcpJ / tcpN/toxT / tcpF / tcpE / tcpT / tcpS / tcpD / tcpR / tcpC / tcpQ / tcpB / tcpA / tcpH / tcpP / tcpI 491375..535061 43686


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-383)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51273.19 Da        Isoelectric Point: 4.9109

>T144892 WP_032472260.1 NZ_CP046747:532230-533591 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFIFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

>T144892 NZ_CP062245:c1265800-1265693 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17024.48 Da        Isoelectric Point: 10.7084

>AT144892 WP_044127591.1 NZ_CP046747:533588-534055 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKSATHSSKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSTDALKSLLMDGEDG

Download         Length: 468 bp

>AT144892 NZ_CP062245:1265847-1265913 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References