Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 528354..528882 Replicon chromosome
Accession NZ_CP046746
Organism Vibrio cholerae strain 3566-08

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag GPW95_RS16855 Protein ID WP_000221352.1
Coordinates 528354..528644 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Q0JPP0
Locus tag GPW95_RS16860 Protein ID WP_019829909.1
Coordinates 528634..528882 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW95_RS16825 524093..524590 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GPW95_RS16830 524587..524859 - 273 WP_019829878.1 DUF1778 domain-containing protein -
GPW95_RS16835 525849..526019 + 171 WP_000483444.1 DUF645 family protein -
GPW95_RS16840 526224..526721 + 498 WP_005526565.1 GNAT family N-acetyltransferase -
GPW95_RS19295 526777..526839 + 63 Protein_480 acetyltransferase -
GPW95_RS16845 526856..527494 + 639 WP_019829928.1 hypothetical protein -
GPW95_RS16850 527648..528226 + 579 WP_032473189.1 DJ-1/PfpI family protein -
GPW95_RS16855 528354..528644 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPW95_RS16860 528634..528882 - 249 WP_019829909.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPW95_RS16865 529093..529746 + 654 WP_019829910.1 peptidoglycan DD-metalloendopeptidase family protein -
GPW95_RS16875 529911..530327 + 417 WP_019829470.1 hypothetical protein -
GPW95_RS16880 530481..531128 + 648 WP_032473193.1 glutathione S-transferase family protein -
GPW95_RS16885 531274..531687 + 414 WP_032473194.1 hypothetical protein -
GPW95_RS16890 531698..533019 - 1322 Protein_489 IS4 family transposase -
GPW95_RS16895 533123..533563 + 441 WP_233269341.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 487525..541374 53849
- inside Integron - - 490782..540962 50180


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T144891 WP_000221352.1 NZ_CP046746:c528644-528354 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T144891 NZ_CP062245:c1265265-1265158 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8967.31 Da        Isoelectric Point: 4.1079

>AT144891 WP_019829909.1 NZ_CP046746:c528882-528634 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAITKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT144891 NZ_CP062245:1265312-1265378 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q0JPP0

References