Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 501063..501601 Replicon chromosome
Accession NZ_CP046746
Organism Vibrio cholerae strain 3566-08

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag GPW95_RS16630 Protein ID WP_000802136.1
Coordinates 501063..501362 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag GPW95_RS16635 Protein ID WP_001107719.1
Coordinates 501359..501601 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW95_RS19275 496259..496330 + 72 WP_229767290.1 DUF3265 domain-containing protein -
GPW95_RS16580 496386..496733 + 348 WP_032473160.1 hypothetical protein -
GPW95_RS16585 496730..496840 + 111 WP_114732487.1 DUF3265 domain-containing protein -
GPW95_RS16590 496877..497416 + 540 WP_000884558.1 hydrolase -
GPW95_RS16595 497580..498404 + 825 WP_148508194.1 hypothetical protein -
GPW95_RS19280 498397..498465 + 69 Protein_431 DUF3265 domain-containing protein -
GPW95_RS16600 498551..498922 + 372 WP_032473159.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
GPW95_RS16605 498979..499071 + 93 WP_152554679.1 acetyltransferase -
GPW95_RS16610 499073..499531 + 459 WP_032473158.1 GNAT family N-acetyltransferase -
GPW95_RS16615 499686..500300 + 615 WP_032473157.1 hypothetical protein -
GPW95_RS16620 500465..500842 - 378 WP_000734783.1 PEGA domain-containing protein -
GPW95_RS16630 501063..501362 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPW95_RS16635 501359..501601 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
GPW95_RS16640 501818..502306 + 489 WP_000424237.1 hypothetical protein -
GPW95_RS16645 502514..503350 + 837 WP_233275519.1 hypothetical protein -
GPW95_RS16650 503540..503926 + 387 WP_043881269.1 hypothetical protein -
GPW95_RS16655 503983..504045 + 63 Protein_442 general secretion pathway protein GspI -
GPW95_RS16660 504063..504497 + 435 WP_001887495.1 GNAT family N-acetyltransferase -
GPW95_RS16665 504644..505132 + 489 WP_000110032.1 GNAT family N-acetyltransferase -
GPW95_RS16670 505429..505611 + 183 WP_032473221.1 DUF645 family protein -
GPW95_RS16675 505807..506289 + 483 WP_032473215.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 487525..541374 53849
- inside Integron - - 490782..540962 50180


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T144887 WP_000802136.1 NZ_CP046746:c501362-501063 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T144887 NZ_CP062245:248788-249186 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT144887 WP_001107719.1 NZ_CP046746:c501601-501359 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT144887 NZ_CP062245:248492-248785 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
PDB 7R5A
PDB 7B22
AlphaFold DB A0A151JFU4

References