Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 501063..501601 | Replicon | chromosome |
| Accession | NZ_CP046746 | ||
| Organism | Vibrio cholerae strain 3566-08 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q9KMJ0 |
| Locus tag | GPW95_RS16630 | Protein ID | WP_000802136.1 |
| Coordinates | 501063..501362 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P58093 |
| Locus tag | GPW95_RS16635 | Protein ID | WP_001107719.1 |
| Coordinates | 501359..501601 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPW95_RS19275 | 496259..496330 | + | 72 | WP_229767290.1 | DUF3265 domain-containing protein | - |
| GPW95_RS16580 | 496386..496733 | + | 348 | WP_032473160.1 | hypothetical protein | - |
| GPW95_RS16585 | 496730..496840 | + | 111 | WP_114732487.1 | DUF3265 domain-containing protein | - |
| GPW95_RS16590 | 496877..497416 | + | 540 | WP_000884558.1 | hydrolase | - |
| GPW95_RS16595 | 497580..498404 | + | 825 | WP_148508194.1 | hypothetical protein | - |
| GPW95_RS19280 | 498397..498465 | + | 69 | Protein_431 | DUF3265 domain-containing protein | - |
| GPW95_RS16600 | 498551..498922 | + | 372 | WP_032473159.1 | MazG nucleotide pyrophosphohydrolase domain-containing protein | - |
| GPW95_RS16605 | 498979..499071 | + | 93 | WP_152554679.1 | acetyltransferase | - |
| GPW95_RS16610 | 499073..499531 | + | 459 | WP_032473158.1 | GNAT family N-acetyltransferase | - |
| GPW95_RS16615 | 499686..500300 | + | 615 | WP_032473157.1 | hypothetical protein | - |
| GPW95_RS16620 | 500465..500842 | - | 378 | WP_000734783.1 | PEGA domain-containing protein | - |
| GPW95_RS16630 | 501063..501362 | - | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPW95_RS16635 | 501359..501601 | - | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| GPW95_RS16640 | 501818..502306 | + | 489 | WP_000424237.1 | hypothetical protein | - |
| GPW95_RS16645 | 502514..503350 | + | 837 | WP_233275519.1 | hypothetical protein | - |
| GPW95_RS16650 | 503540..503926 | + | 387 | WP_043881269.1 | hypothetical protein | - |
| GPW95_RS16655 | 503983..504045 | + | 63 | Protein_442 | general secretion pathway protein GspI | - |
| GPW95_RS16660 | 504063..504497 | + | 435 | WP_001887495.1 | GNAT family N-acetyltransferase | - |
| GPW95_RS16665 | 504644..505132 | + | 489 | WP_000110032.1 | GNAT family N-acetyltransferase | - |
| GPW95_RS16670 | 505429..505611 | + | 183 | WP_032473221.1 | DUF645 family protein | - |
| GPW95_RS16675 | 505807..506289 | + | 483 | WP_032473215.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 487525..541374 | 53849 | |
| - | inside | Integron | - | - | 490782..540962 | 50180 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11589.29 Da Isoelectric Point: 9.9232
>T144887 WP_000802136.1 NZ_CP046746:c501362-501063 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T144887 NZ_CP062245:248788-249186 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8964.84 Da Isoelectric Point: 4.1677
>AT144887 WP_001107719.1 NZ_CP046746:c501601-501359 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT144887 NZ_CP062245:248492-248785 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|