Detailed information of TA system TA144886

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 983519..985194
• Replicon: chromosome
• Accession: NZ_CP046745
• Organism: Vibrio cholerae strain 3566-08

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: GPW95_RS04655
• Protein ID: WP_032473081.1
• Coordinates: 983983..985194 (+)
• Length: 404 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0X8LPP8
• Locus tag: GPW95_RS04650
• Protein ID: WP_000649312.1
• Coordinates: 983519..983986 (+)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPW95_RS04620	978718..978939	-	222	WP_005378664.1	AlpA family transcriptional regulator	-
GPW95_RS04625	979017..980006	+	990	WP_032473084.1	50S ribosome-binding GTPase	-
GPW95_RS04630	980117..980563	+	447	WP_032473083.1	hypothetical protein	-
GPW95_RS04635	980604..981248	-	645	WP_032473082.1	inovirus Gp2 family protein	-
GPW95_RS04640	981415..982449	-	1035	WP_005378669.1	hypothetical protein	-
GPW95_RS04645	982594..983265	+	672	WP_001888975.1	hypothetical protein	-
GPW95_RS04650	983519..983986	+	468	WP_000649312.1	DUF4065 domain-containing protein	Antitoxin
GPW95_RS04655	983983..985194	+	1212	WP_032473081.1	RelA/SpoT domain-containing protein	Toxin
GPW95_RS04660	985440..986549	-	1110	WP_001888924.1	tRNA (uridine(54)-C5)-methyltransferase TrmA	-
GPW95_RS04665	986947..988779	+	1833	WP_019829931.1	TonB-dependent receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	981415..992067	10652

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (86-226)

Antitoxin

• Antitoxin SocA-like, Panacea domain (32-123)

Sequences

Toxin

Protein

• Length: 404 a.a.
• Molecular weight: 45807.63 Da
• Isoelectric Point: 5.2762

>T144886 WP_032473081.1 NZ_CP046745:983983-985194 [Vibrio cholerae]
VSDKEKRVVSFQIDDTPTAEQASKNFQDDYELCFQDFLERTVDESAAEDFSYSNNGVKKAGRRLRKKEGDLKSATATIQQ
FRAAHEKPLNTIAYLVGRCCRELGIDVKPVTRLKRLETIVDKLQRKSLDGETTNATCVTNMNDIGGCRAIFPDLESLEKA
KERLQVTVEKVGRIKIKDIDDYIANPKPNDCGYRSLHVIYRYDHASGKSFNIEAQLRTRLQHLWATTVEIVDILEGTKIK
THSHSPDEDKEKLQVQWEELLSIMSQYIADAEGAIELSNDNRTQFSNRLIELNREINALSRLRSFKILSEKVEGCRDGSI
EHVLLVIDETSLEMIFSEEFENYTQAISVYNAAEKMTRSHARLNTLLISTKNMGQLSEAYPNYLGDCASFITLLEDAMQS
GQN

Nucleotide

• Length: 1212 bp

>T144886 NZ_CP062245:c242726-242448 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17581.02 Da
• Isoelectric Point: 7.5659

>AT144886 WP_000649312.1 NZ_CP046745:983519-983986 [Vibrio cholerae]
MKAYHTYSAVDVAWSLLKHAKEQGKCFSNLQLQKLTYVCHGLSLAHFQRPLVVDDVFAWKFGPVVPSVYFRFKSYGSNVI
TEQCDVVLDHESESIVKDVVSQLGHLTGPQLVDLTHREGSPWHQVWDGTHQKVIPDHLIQAHYTQIKQSGRTASL

Nucleotide

• Length: 468 bp

>AT144886 NZ_CP062245:c242989-242729 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0X8LPP8