Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 47891..49716 Replicon chromosome
Accession NZ_CP046745
Organism Vibrio cholerae strain 3566-08

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GPW95_RS00235 Protein ID WP_032472659.1
Coordinates 47891..49252 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GPW95_RS00240 Protein ID WP_032472658.1
Coordinates 49249..49716 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW95_RS00200 42936..43364 + 429 WP_019830040.1 DUF2787 domain-containing protein -
GPW95_RS00205 43415..43861 + 447 WP_019830041.1 DUF2787 domain-containing protein -
GPW95_RS19035 43964..44950 + 987 Protein_40 GTPase family protein -
GPW95_RS00220 44983..45624 - 642 WP_032472660.1 inovirus Gp2 family protein -
GPW95_RS00225 47073..47273 - 201 WP_019830047.1 AlpA family transcriptional regulator -
GPW95_RS00235 47891..49252 + 1362 WP_032472659.1 type II toxin-antitoxin system HipA family toxin Toxin
GPW95_RS00240 49249..49716 + 468 WP_032472658.1 helix-turn-helix transcriptional regulator Antitoxin
GPW95_RS00245 50144..50722 + 579 WP_000109982.1 class I SAM-dependent methyltransferase -
GPW95_RS00250 50726..53662 + 2937 WP_032472657.1 DEAD/DEAH box helicase family protein -
GPW95_RS00255 53733..54433 + 701 Protein_47 NERD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-383)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51377.35 Da        Isoelectric Point: 5.0463

>T144885 WP_032472659.1 NZ_CP046745:47891-49252 [Vibrio cholerae]
MEELTVQAFIRGQWIDIGIISFPKSSQHNFRVTELNYLSDYALKHYDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWELL

Download         Length: 1362 bp

>T144885 NZ_CP062244:c4569657-4569316 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17073.60 Da        Isoelectric Point: 10.7084

>AT144885 WP_032472658.1 NZ_CP046745:49249-49716 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKNATHSIKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Download         Length: 468 bp

>AT144885 NZ_CP062244:4569652-4569728 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References