Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 695848..696388 Replicon chromosome
Accession NZ_CP046743
Organism Vibrio cholerae strain 3569-08

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag GPW72_RS03720 Protein ID WP_000277238.1
Coordinates 696119..696388 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag GPW72_RS03715 Protein ID WP_001258569.1
Coordinates 695848..696126 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW72_RS03685 691347..692258 - 912 WP_000174843.1 hypothetical protein -
GPW72_RS03690 692451..692885 - 435 WP_000453680.1 GNAT family N-acetyltransferase -
GPW72_RS03695 693042..693665 - 624 WP_000247072.1 DUF1349 domain-containing protein -
GPW72_RS03700 693877..694047 - 171 WP_000483442.1 DUF645 family protein -
GPW72_RS03705 694351..695064 - 714 WP_000123659.1 Fic family protein -
GPW72_RS03710 695314..695493 - 180 Protein_700 DUF645 family protein -
GPW72_RS03715 695848..696126 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GPW72_RS03720 696119..696388 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
GPW72_RS03725 696585..696766 - 182 Protein_703 DUF645 family protein -
GPW72_RS19240 697120..697230 - 111 WP_080314579.1 DUF645 family protein -
GPW72_RS03740 697605..698120 - 516 WP_001894921.1 lipocalin family protein -
GPW72_RS03745 698706..699143 - 438 WP_001894912.1 hypothetical protein -
GPW72_RS03750 699284..699757 - 474 WP_001894959.1 GrpB family protein -
GPW72_RS03755 699784..699861 - 78 WP_080314602.1 DUF3265 domain-containing protein -
GPW72_RS03760 699890..700273 - 384 WP_000473945.1 hypothetical protein -
GPW72_RS03765 700412..701182 - 771 WP_000399050.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 575627..724145 148518
- inside Integron - - 575627..717201 141574


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T144882 WP_000277238.1 NZ_CP046743:696119-696388 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T144882 NZ_CP062244:4342725-4342898 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT144882 WP_001258569.1 NZ_CP046743:695848-696126 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT144882 NZ_CP062244:4342401-4342697 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References