Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/YafQ-RelB |
Location | 695848..696388 | Replicon | chromosome |
Accession | NZ_CP046743 | ||
Organism | Vibrio cholerae strain 3569-08 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A151JGK8 |
Locus tag | GPW72_RS03720 | Protein ID | WP_000277238.1 |
Coordinates | 696119..696388 (+) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | Q9KML3 |
Locus tag | GPW72_RS03715 | Protein ID | WP_001258569.1 |
Coordinates | 695848..696126 (+) | Length | 93 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GPW72_RS03685 | 691347..692258 | - | 912 | WP_000174843.1 | hypothetical protein | - |
GPW72_RS03690 | 692451..692885 | - | 435 | WP_000453680.1 | GNAT family N-acetyltransferase | - |
GPW72_RS03695 | 693042..693665 | - | 624 | WP_000247072.1 | DUF1349 domain-containing protein | - |
GPW72_RS03700 | 693877..694047 | - | 171 | WP_000483442.1 | DUF645 family protein | - |
GPW72_RS03705 | 694351..695064 | - | 714 | WP_000123659.1 | Fic family protein | - |
GPW72_RS03710 | 695314..695493 | - | 180 | Protein_700 | DUF645 family protein | - |
GPW72_RS03715 | 695848..696126 | + | 279 | WP_001258569.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
GPW72_RS03720 | 696119..696388 | + | 270 | WP_000277238.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
GPW72_RS03725 | 696585..696766 | - | 182 | Protein_703 | DUF645 family protein | - |
GPW72_RS19240 | 697120..697230 | - | 111 | WP_080314579.1 | DUF645 family protein | - |
GPW72_RS03740 | 697605..698120 | - | 516 | WP_001894921.1 | lipocalin family protein | - |
GPW72_RS03745 | 698706..699143 | - | 438 | WP_001894912.1 | hypothetical protein | - |
GPW72_RS03750 | 699284..699757 | - | 474 | WP_001894959.1 | GrpB family protein | - |
GPW72_RS03755 | 699784..699861 | - | 78 | WP_080314602.1 | DUF3265 domain-containing protein | - |
GPW72_RS03760 | 699890..700273 | - | 384 | WP_000473945.1 | hypothetical protein | - |
GPW72_RS03765 | 700412..701182 | - | 771 | WP_000399050.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 575627..724145 | 148518 | |
- | inside | Integron | - | - | 575627..717201 | 141574 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10406.11 Da Isoelectric Point: 9.5084
>T144882 WP_000277238.1 NZ_CP046743:696119-696388 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF
Download Length: 270 bp
>T144882 NZ_CP062244:4342725-4342898 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 93 a.a. Molecular weight: 10088.58 Da Isoelectric Point: 6.0728
>AT144882 WP_001258569.1 NZ_CP046743:695848-696126 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV
Download Length: 279 bp
>AT144882 NZ_CP062244:4342401-4342697 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A151JGK8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A151KTP9 |