Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 690095..690633 Replicon chromosome
Accession NZ_CP046743
Organism Vibrio cholerae strain 3569-08

Toxin (Protein)


Gene name parE Uniprot ID A0A0K9UM73
Locus tag GPW72_RS03670 Protein ID WP_000802138.1
Coordinates 690334..690633 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A271VK51
Locus tag GPW72_RS03665 Protein ID WP_001107720.1
Coordinates 690095..690337 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 575627..724145 148518
- inside Integron - - 575627..717201 141574


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11617.34 Da        Isoelectric Point: 9.8184

>T144881 WP_000802138.1 NZ_CP046743:690334-690633 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKYPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T144881 NZ_CP062244:c3693447-3693340 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8950.82 Da        Isoelectric Point: 4.1677

>AT144881 WP_001107720.1 NZ_CP046743:690095-690337 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT144881 NZ_CP062244:3693496-3693562 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UM73

Antitoxin

Source ID Structure
AlphaFold DB A0A271VK51

References