Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DhiAT/- |
| Location | 666177..666961 | Replicon | chromosome |
| Accession | NZ_CP046743 | ||
| Organism | Vibrio cholerae strain 3569-08 | ||
Toxin (Protein)
| Gene name | dhiT | Uniprot ID | A0A086SLD6 |
| Locus tag | GPW72_RS03445 | Protein ID | WP_001114075.1 |
| Coordinates | 666692..666961 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | dhiA | Uniprot ID | C3LUY7 |
| Locus tag | GPW72_RS03440 | Protein ID | WP_000921692.1 |
| Coordinates | 666177..666698 (-) | Length | 174 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPW72_RS19220 | 661611..661649 | - | 39 | WP_082798268.1 | hypothetical protein | - |
| GPW72_RS19225 | 661703..661846 | - | 144 | Protein_646 | DUF645 family protein | - |
| GPW72_RS03395 | 662221..662499 | - | 279 | WP_000280324.1 | DUF3709 domain-containing protein | - |
| GPW72_RS03405 | 662737..663270 | - | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | - |
| GPW72_RS03410 | 663267..663587 | - | 321 | WP_001909340.1 | DUF1778 domain-containing protein | - |
| GPW72_RS03415 | 663907..664128 | - | 222 | WP_012705854.1 | DUF3709 domain-containing protein | - |
| GPW72_RS03420 | 664149..664309 | - | 161 | Protein_651 | DUF3709 domain-containing protein | - |
| GPW72_RS03425 | 664399..665037 | - | 639 | WP_000230118.1 | HD domain-containing protein | - |
| GPW72_RS03430 | 665202..666038 | - | 837 | WP_000242986.1 | hypothetical protein | - |
| GPW72_RS03435 | 666007..666120 | - | 114 | WP_001894981.1 | hypothetical protein | - |
| GPW72_RS03440 | 666177..666698 | - | 522 | WP_000921692.1 | DUF2442 domain-containing protein | Antitoxin |
| GPW72_RS03445 | 666692..666961 | - | 270 | WP_001114075.1 | DUF4160 domain-containing protein | Toxin |
| GPW72_RS03455 | 667769..668251 | - | 483 | WP_000422940.1 | GNAT family N-acetyltransferase | - |
| GPW72_RS03465 | 668839..669267 | - | 429 | WP_000620002.1 | N-acetyltransferase | - |
| GPW72_RS03470 | 669841..670845 | - | 1005 | WP_000964920.1 | LD-carboxypeptidase | - |
| GPW72_RS03475 | 671061..671243 | - | 183 | WP_000923182.1 | DUF645 family protein | - |
| GPW72_RS03480 | 671411..671512 | - | 102 | WP_079993098.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 575627..724145 | 148518 | |
| - | inside | Integron | - | - | 575627..717201 | 141574 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10310.94 Da Isoelectric Point: 6.6303
>T144880 WP_001114075.1 NZ_CP046743:c666961-666692 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC
Download Length: 270 bp
>T144880 NZ_CP046743:c666961-666692 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAAC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAAC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA
Antitoxin
Download Length: 174 a.a. Molecular weight: 19439.04 Da Isoelectric Point: 6.7342
>AT144880 WP_000921692.1 NZ_CP046743:c666698-666177 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKTPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKTPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI
Download Length: 522 bp
>AT144880 NZ_CP046743:c666698-666177 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAACACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAACACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A086SLD6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | C3LUY7 |