Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /DUF1778(antitoxin) |
| Location | 662737..663587 | Replicon | chromosome |
| Accession | NZ_CP046743 | ||
| Organism | Vibrio cholerae strain 3569-08 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9KM94 |
| Locus tag | GPW72_RS03405 | Protein ID | WP_000118351.1 |
| Coordinates | 662737..663270 (-) | Length | 178 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | GPW72_RS03410 | Protein ID | WP_001909340.1 |
| Coordinates | 663267..663587 (-) | Length | 107 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPW72_RS03365 | 658569..659363 | - | 795 | WP_001911581.1 | hypothetical protein | - |
| GPW72_RS03370 | 659459..659704 | - | 246 | WP_000643598.1 | hypothetical protein | - |
| GPW72_RS03375 | 659691..659957 | - | 267 | WP_000589156.1 | BrnT family toxin | - |
| GPW72_RS03380 | 660142..660804 | - | 663 | WP_000960654.1 | hypothetical protein | - |
| GPW72_RS03385 | 660932..661399 | - | 468 | WP_001289288.1 | OsmC family protein | - |
| GPW72_RS19220 | 661611..661649 | - | 39 | WP_082798268.1 | hypothetical protein | - |
| GPW72_RS19225 | 661703..661846 | - | 144 | Protein_646 | DUF645 family protein | - |
| GPW72_RS03395 | 662221..662499 | - | 279 | WP_000280324.1 | DUF3709 domain-containing protein | - |
| GPW72_RS03405 | 662737..663270 | - | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | Toxin |
| GPW72_RS03410 | 663267..663587 | - | 321 | WP_001909340.1 | DUF1778 domain-containing protein | Antitoxin |
| GPW72_RS03415 | 663907..664128 | - | 222 | WP_012705854.1 | DUF3709 domain-containing protein | - |
| GPW72_RS03420 | 664149..664309 | - | 161 | Protein_651 | DUF3709 domain-containing protein | - |
| GPW72_RS03425 | 664399..665037 | - | 639 | WP_000230118.1 | HD domain-containing protein | - |
| GPW72_RS03430 | 665202..666038 | - | 837 | WP_000242986.1 | hypothetical protein | - |
| GPW72_RS03435 | 666007..666120 | - | 114 | WP_001894981.1 | hypothetical protein | - |
| GPW72_RS03440 | 666177..666698 | - | 522 | WP_000921692.1 | DUF2442 domain-containing protein | - |
| GPW72_RS03445 | 666692..666961 | - | 270 | WP_001114075.1 | DUF4160 domain-containing protein | - |
| GPW72_RS03455 | 667769..668251 | - | 483 | WP_000422940.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 575627..724145 | 148518 | |
| - | inside | Integron | - | - | 575627..717201 | 141574 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 20171.46 Da Isoelectric Point: 9.1432
>T144879 WP_000118351.1 NZ_CP046743:c663270-662737 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ
Download Length: 534 bp
>T144879 NZ_CP062244:c3227814-3227500 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 107 a.a. Molecular weight: 11759.53 Da Isoelectric Point: 4.9309
>AT144879 WP_001909340.1 NZ_CP046743:c663587-663267 [Vibrio cholerae]
MAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK
MAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK
Download Length: 321 bp
>AT144879 NZ_CP062244:c3227503-3227087 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|