Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-Phd |
| Location | 582068..582615 | Replicon | chromosome |
| Accession | NZ_CP046743 | ||
| Organism | Vibrio cholerae strain 3569-08 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q9KM92 |
| Locus tag | GPW72_RS02635 | Protein ID | WP_000229317.1 |
| Coordinates | 582068..582370 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KM93 |
| Locus tag | GPW72_RS02640 | Protein ID | WP_000861987.1 |
| Coordinates | 582358..582615 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPW72_RS02585 | 577420..577704 | + | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| GPW72_RS02590 | 577701..577979 | + | 279 | WP_000578476.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| GPW72_RS02595 | 578118..578513 | - | 396 | WP_001000867.1 | hypothetical protein | - |
| GPW72_RS02605 | 578764..578889 | - | 126 | WP_001905700.1 | DUF645 family protein | - |
| GPW72_RS02610 | 579188..579709 | - | 522 | WP_000921691.1 | DUF2442 domain-containing protein | - |
| GPW72_RS02615 | 579703..579972 | - | 270 | WP_001114075.1 | DUF4160 domain-containing protein | - |
| GPW72_RS02620 | 580003..580107 | - | 105 | WP_099607150.1 | acetyltransferase | - |
| GPW72_RS02625 | 580164..580763 | - | 600 | WP_001891245.1 | glutathione S-transferase N-terminal domain-containing protein | - |
| GPW72_RS02630 | 580913..581797 | - | 885 | WP_000842472.1 | DUF3800 domain-containing protein | - |
| GPW72_RS02635 | 582068..582370 | - | 303 | WP_000229317.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPW72_RS02640 | 582358..582615 | - | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GPW72_RS02650 | 582817..583350 | - | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | - |
| GPW72_RS19170 | 583347..583772 | - | 426 | WP_001882332.1 | DUF1778 domain-containing protein | - |
| GPW72_RS02660 | 583839..584210 | - | 372 | WP_001164080.1 | nucleotide pyrophosphohydrolase | - |
| GPW72_RS02665 | 584351..584638 | - | 288 | WP_000426470.1 | hypothetical protein | - |
| GPW72_RS02670 | 584790..585458 | - | 669 | WP_000043871.1 | hypothetical protein | - |
| GPW72_RS02675 | 585689..585961 | + | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| GPW72_RS02680 | 585958..586455 | + | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| GPW72_RS02690 | 586657..586809 | - | 153 | WP_001884520.1 | DUF645 family protein | - |
| GPW72_RS02695 | 587131..587586 | - | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 575627..724145 | 148518 | |
| - | inside | Integron | - | - | 575627..717201 | 141574 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11726.68 Da Isoelectric Point: 5.1972
>T144869 WP_000229317.1 NZ_CP046743:c582370-582068 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T144869 NZ_CP062244:c1639890-1639603 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT144869 WP_000861987.1 NZ_CP046743:c582615-582358 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT144869 NZ_CP062244:c1640129-1639890 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q9KM92 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1T4SLM9 |