Detailed information of TA system TA144868

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): dhiT-phd/-
• Location: 579703..580107
• Replicon: chromosome
• Accession: NZ_CP046743
• Organism: Vibrio cholerae strain 3569-08

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: A0A086SLD6
• Locus tag: GPW72_RS02615
• Protein ID: WP_001114075.1
• Coordinates: 579703..579972 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: GPW72_RS02620
• Protein ID: WP_099607150.1
• Coordinates: 580003..580107 (-)
• Length: 35 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPW72_RS02575	576114..576527	-	414	WP_000049420.1	VOC family protein	-
GPW72_RS02580	576711..577226	-	516	WP_000343779.1	GNAT family N-acetyltransferase	-
GPW72_RS02585	577420..577704	+	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
GPW72_RS02590	577701..577979	+	279	WP_000578476.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
GPW72_RS02595	578118..578513	-	396	WP_001000867.1	hypothetical protein	-
GPW72_RS02605	578764..578889	-	126	WP_001905700.1	DUF645 family protein	-
GPW72_RS02610	579188..579709	-	522	WP_000921691.1	DUF2442 domain-containing protein	-
GPW72_RS02615	579703..579972	-	270	WP_001114075.1	DUF4160 domain-containing protein	Toxin
GPW72_RS02620	580003..580107	-	105	WP_099607150.1	acetyltransferase	Antitoxin
GPW72_RS02625	580164..580763	-	600	WP_001891245.1	glutathione S-transferase N-terminal domain-containing protein	-
GPW72_RS02630	580913..581797	-	885	WP_000842472.1	DUF3800 domain-containing protein	-
GPW72_RS02635	582068..582370	-	303	WP_000229317.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GPW72_RS02640	582358..582615	-	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
GPW72_RS02650	582817..583350	-	534	WP_000118351.1	GNAT family N-acetyltransferase	-
GPW72_RS19170	583347..583772	-	426	WP_001882332.1	DUF1778 domain-containing protein	-
GPW72_RS02660	583839..584210	-	372	WP_001164080.1	nucleotide pyrophosphohydrolase	-
GPW72_RS02665	584351..584638	-	288	WP_000426470.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	575627..724145	148518
	-	inside	Integron	-	-	575627..717201	141574

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10310.94 Da
• Isoelectric Point: 6.6303

>T144868 WP_001114075.1 NZ_CP046743:c579972-579703 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Nucleotide

• Length: 270 bp

>T144868 NZ_CP062244:c1586433-1585111 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Protein

• Length: 35 a.a.
• Molecular weight: 3991.79 Da
• Isoelectric Point: 9.2853

>AT144868 WP_099607150.1 NZ_CP046743:c580107-580003 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Nucleotide

• Length: 105 bp

>AT144868 NZ_CP062244:c1586699-1586433 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: A0A086SLD6