144867

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 579188..579972 Replicon chromosome
Accession NZ_CP046743
Organism Vibrio cholerae strain 3569-08

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag GPW72_RS02615 Protein ID WP_001114075.1
Coordinates 579703..579972 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag GPW72_RS02610 Protein ID WP_000921691.1
Coordinates 579188..579709 (-) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW72_RS02575 576114..576527 - 414 WP_000049420.1 VOC family protein -
GPW72_RS02580 576711..577226 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
GPW72_RS02585 577420..577704 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GPW72_RS02590 577701..577979 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
GPW72_RS02595 578118..578513 - 396 WP_001000867.1 hypothetical protein -
GPW72_RS02605 578764..578889 - 126 WP_001905700.1 DUF645 family protein -
GPW72_RS02610 579188..579709 - 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
GPW72_RS02615 579703..579972 - 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
GPW72_RS02620 580003..580107 - 105 WP_099607150.1 acetyltransferase -
GPW72_RS02625 580164..580763 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GPW72_RS02630 580913..581797 - 885 WP_000842472.1 DUF3800 domain-containing protein -
GPW72_RS02635 582068..582370 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPW72_RS02640 582358..582615 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GPW72_RS02650 582817..583350 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
GPW72_RS19170 583347..583772 - 426 WP_001882332.1 DUF1778 domain-containing protein -
GPW72_RS02660 583839..584210 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GPW72_RS02665 584351..584638 - 288 WP_000426470.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 575627..724145 148518
- inside Integron - - 575627..717201 141574


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T144867 WP_001114075.1 NZ_CP046743:c579972-579703 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T144867 NZ_CP062244:1503543-1503719 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT144867 WP_000921691.1 NZ_CP046743:c579709-579188 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT144867 NZ_CP062244:1503765-1504181 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References