144866

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 577420..577979 Replicon chromosome
Accession NZ_CP046743
Organism Vibrio cholerae strain 3569-08

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GPW72_RS02590 Protein ID WP_000578476.1
Coordinates 577701..577979 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GPW72_RS02585 Protein ID WP_000381183.1
Coordinates 577420..577704 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW72_RS02575 576114..576527 - 414 WP_000049420.1 VOC family protein -
GPW72_RS02580 576711..577226 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
GPW72_RS02585 577420..577704 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GPW72_RS02590 577701..577979 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GPW72_RS02595 578118..578513 - 396 WP_001000867.1 hypothetical protein -
GPW72_RS02605 578764..578889 - 126 WP_001905700.1 DUF645 family protein -
GPW72_RS02610 579188..579709 - 522 WP_000921691.1 DUF2442 domain-containing protein -
GPW72_RS02615 579703..579972 - 270 WP_001114075.1 DUF4160 domain-containing protein -
GPW72_RS02620 580003..580107 - 105 WP_099607150.1 acetyltransferase -
GPW72_RS02625 580164..580763 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GPW72_RS02630 580913..581797 - 885 WP_000842472.1 DUF3800 domain-containing protein -
GPW72_RS02635 582068..582370 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPW72_RS02640 582358..582615 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 575627..724145 148518
- inside Integron - - 575627..717201 141574


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T144866 WP_000578476.1 NZ_CP046743:577701-577979 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T144866 NZ_CP062244:c1408184-1407990 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT144866 WP_000381183.1 NZ_CP046743:577420-577704 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT144866 NZ_CP062244:1407813-1407991 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References