Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 627424..627989 Replicon chromosome
Accession NZ_CP046741
Organism Vibrio cholerae strain 3523-03

Toxin (Protein)


Gene name relE Uniprot ID D7HCW8
Locus tag GPW86_RS03540 Protein ID WP_000869999.1
Coordinates 627702..627989 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0IIK3
Locus tag GPW86_RS03535 Protein ID WP_000086649.1
Coordinates 627424..627705 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW86_RS03500 622854..623036 + 183 WP_123011680.1 DUF645 family protein -
GPW86_RS03505 623235..623741 + 507 WP_123011681.1 GNAT family N-acetyltransferase -
GPW86_RS03510 623885..624391 + 507 WP_123011681.1 GNAT family N-acetyltransferase -
GPW86_RS03515 624535..625071 + 537 WP_095474066.1 hypothetical protein -
GPW86_RS03520 625220..625696 + 477 WP_102787218.1 hypothetical protein -
GPW86_RS03525 625719..626678 - 960 WP_123011654.1 IS30 family transposase -
GPW86_RS03535 627424..627705 + 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPW86_RS03540 627702..627989 + 288 WP_000869999.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPW86_RS03545 628136..628606 - 471 WP_000784954.1 RES family NAD+ phosphorylase -
GPW86_RS03550 628606..629058 - 453 WP_000024295.1 DUF2384 domain-containing protein -
GPW86_RS03560 629363..629650 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPW86_RS03565 629661..629978 + 318 WP_001232701.1 HigA family addiction module antidote protein -
GPW86_RS03570 630120..630500 + 381 WP_113601670.1 MmcQ/YjbR family DNA-binding protein -
GPW86_RS03575 630536..631480 - 945 WP_038964128.1 IS110 family transposase -
GPW86_RS03580 631680..631793 + 114 WP_123011836.1 DUF3265 domain-containing protein -
GPW86_RS03585 631820..632293 + 474 WP_123011684.1 GrpB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 443489..637173 193684
- flank IS/Tn - - 630536..631480 944
- inside Integron - - 573974..638391 64417


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10997.74 Da        Isoelectric Point: 6.0710

>T144863 WP_000869999.1 NZ_CP046741:627702-627989 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Download         Length: 288 bp

>T144863 NZ_CP062244:c1264731-1264624 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10361.93 Da        Isoelectric Point: 5.1548

>AT144863 WP_000086649.1 NZ_CP046741:627424-627705 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT144863 NZ_CP062244:1264779-1264845 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3AEF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UIW4

References