Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 620641..621219 | Replicon | chromosome |
| Accession | NZ_CP046741 | ||
| Organism | Vibrio cholerae strain 3523-03 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | GPW86_RS03470 | Protein ID | WP_184476341.1 |
| Coordinates | 620641..620958 (-) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A366AI09 |
| Locus tag | GPW86_RS03475 | Protein ID | WP_000557291.1 |
| Coordinates | 620977..621219 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPW86_RS19390 | 615798..615977 | + | 180 | WP_174500466.1 | DUF645 family protein | - |
| GPW86_RS03440 | 616023..616061 | + | 39 | WP_108315918.1 | hypothetical protein | - |
| GPW86_RS03445 | 616267..616731 | + | 465 | WP_032473198.1 | ASCH domain-containing protein | - |
| GPW86_RS03450 | 617134..618093 | - | 960 | WP_123011654.1 | IS30 family transposase | - |
| GPW86_RS03455 | 618328..618843 | + | 516 | WP_001894921.1 | lipocalin family protein | - |
| GPW86_RS03460 | 618875..619834 | - | 960 | WP_123011654.1 | IS30 family transposase | - |
| GPW86_RS03465 | 620051..620506 | + | 456 | WP_071180673.1 | GNAT family N-acetyltransferase | - |
| GPW86_RS03470 | 620641..620958 | - | 318 | WP_184476341.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPW86_RS03475 | 620977..621219 | - | 243 | WP_000557291.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GPW86_RS03480 | 621608..621704 | + | 97 | Protein_657 | DUF645 family protein | - |
| GPW86_RS03485 | 621723..621761 | + | 39 | WP_108244118.1 | hypothetical protein | - |
| GPW86_RS03490 | 621939..622256 | - | 318 | WP_123011679.1 | CcdB family protein | - |
| GPW86_RS03495 | 622256..622501 | - | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| GPW86_RS03500 | 622854..623036 | + | 183 | WP_123011680.1 | DUF645 family protein | - |
| GPW86_RS03505 | 623235..623741 | + | 507 | WP_123011681.1 | GNAT family N-acetyltransferase | - |
| GPW86_RS03510 | 623885..624391 | + | 507 | WP_123011681.1 | GNAT family N-acetyltransferase | - |
| GPW86_RS03515 | 624535..625071 | + | 537 | WP_095474066.1 | hypothetical protein | - |
| GPW86_RS03520 | 625220..625696 | + | 477 | WP_102787218.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 443489..637173 | 193684 | |
| - | inside | Integron | - | - | 573974..638391 | 64417 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12198.01 Da Isoelectric Point: 9.7496
>T144862 WP_184476341.1 NZ_CP046741:c620958-620641 [Vibrio cholerae]
MQNKQYKLSHLAQEHLLKIKHYTIENFAETQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSHLAQEHLLKIKHYTIENFAETQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T144862 NZ_CP062244:c475764-475546 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8931.22 Da Isoelectric Point: 5.6630
>AT144862 WP_000557291.1 NZ_CP046741:c621219-620977 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGAAFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGAAFLNTL
Download Length: 243 bp
>AT144862 NZ_CP062244:c476164-475790 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|