Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 595419..595966 Replicon chromosome
Accession NZ_CP046741
Organism Vibrio cholerae strain 3523-03

Toxin (Protein)


Gene name relE Uniprot ID D7HHP0
Locus tag GPW86_RS03265 Protein ID WP_000229320.1
Coordinates 595664..595966 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag GPW86_RS03260 Protein ID WP_000861987.1
Coordinates 595419..595676 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW86_RS03200 590799..590891 + 93 WP_072617168.1 DUF3265 domain-containing protein -
GPW86_RS03205 590975..591238 + 264 WP_071180065.1 hypothetical protein -
GPW86_RS03215 591403..591789 + 387 WP_176471473.1 hypothetical protein -
GPW86_RS03220 591819..591911 + 93 WP_072599414.1 DUF3265 domain-containing protein -
GPW86_RS03225 591956..592285 + 330 WP_114710020.1 hypothetical protein -
GPW86_RS03230 592332..593291 - 960 WP_123011654.1 IS30 family transposase -
GPW86_RS03235 593685..593807 + 123 WP_080478887.1 DUF645 family protein -
GPW86_RS03240 593826..593864 + 39 WP_108254100.1 hypothetical protein -
GPW86_RS03245 594079..594372 + 294 WP_055044996.1 hypothetical protein -
GPW86_RS03250 594358..594801 - 444 WP_001106980.1 hypothetical protein -
GPW86_RS03255 594791..595111 - 321 WP_000752393.1 hypothetical protein -
GPW86_RS03260 595419..595676 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPW86_RS03265 595664..595966 + 303 WP_000229320.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPW86_RS03275 596157..596441 + 285 WP_043993102.1 antibiotic biosynthesis monooxygenase -
GPW86_RS03285 596587..597498 + 912 WP_148039152.1 hypothetical protein -
GPW86_RS03290 597635..598069 + 435 WP_057563745.1 GNAT family N-acetyltransferase -
GPW86_RS03295 598221..598670 + 450 WP_057556343.1 GyrI-like domain-containing protein -
GPW86_RS03300 598657..598785 + 129 WP_080390558.1 DUF3265 domain-containing protein -
GPW86_RS03305 598838..599077 + 240 WP_032479075.1 hypothetical protein -
GPW86_RS03310 599419..600342 + 924 WP_123011669.1 arginase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 443489..637173 193684
- inside Integron - - 573974..638391 64417


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11682.58 Da        Isoelectric Point: 4.8838

>T144861 WP_000229320.1 NZ_CP046741:595664-595966 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKI
SILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T144861 NZ_CP062244:c259380-259039 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT144861 WP_000861987.1 NZ_CP046741:595419-595676 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT144861 NZ_CP062244:c259718-259401 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D7HHP0

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References