Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 524138..524697 | Replicon | chromosome |
| Accession | NZ_CP046741 | ||
| Organism | Vibrio cholerae strain 3523-03 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HHK2 |
| Locus tag | GPW86_RS02620 | Protein ID | WP_000578471.1 |
| Coordinates | 524138..524416 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | GPW86_RS02625 | Protein ID | WP_000381186.1 |
| Coordinates | 524413..524697 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPW86_RS19355 | 519395..519700 | + | 306 | WP_057556432.1 | hypothetical protein | - |
| GPW86_RS02575 | 520018..520146 | + | 129 | WP_001898444.1 | DUF645 family protein | - |
| GPW86_RS02580 | 520162..520200 | + | 39 | WP_113622165.1 | hypothetical protein | - |
| GPW86_RS02585 | 520411..520917 | + | 507 | WP_086467534.1 | hypothetical protein | - |
| GPW86_RS02590 | 520933..521484 | + | 552 | WP_123011632.1 | YfbU family protein | - |
| GPW86_RS02595 | 521625..522107 | + | 483 | WP_123011633.1 | tetratricopeptide repeat protein | - |
| GPW86_RS02600 | 522264..522668 | + | 405 | WP_095459628.1 | DUF1801 domain-containing protein | - |
| GPW86_RS02605 | 522819..523457 | + | 639 | WP_057555220.1 | HNH endonuclease | - |
| GPW86_RS02610 | 523594..523995 | + | 402 | WP_052469078.1 | hypothetical protein | - |
| GPW86_RS02615 | 524052..524165 | + | 114 | WP_123011635.1 | acetyltransferase | - |
| GPW86_RS02620 | 524138..524416 | - | 279 | WP_000578471.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| GPW86_RS02625 | 524413..524697 | - | 285 | WP_000381186.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| GPW86_RS02630 | 524813..525322 | + | 510 | WP_123011636.1 | hypothetical protein | - |
| GPW86_RS02645 | 525915..526859 | - | 945 | WP_038964128.1 | IS110 family transposase | - |
| GPW86_RS02650 | 527094..527171 | + | 78 | WP_069548637.1 | DUF3265 domain-containing protein | - |
| GPW86_RS02655 | 527202..527735 | + | 534 | WP_148039150.1 | hypothetical protein | - |
| GPW86_RS02660 | 527758..528717 | - | 960 | WP_033933230.1 | IS30 family transposase | - |
| GPW86_RS02665 | 528941..529306 | + | 366 | WP_123011639.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 443489..637173 | 193684 | |
| - | inside | Integron | - | - | 444653..571022 | 126369 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10838.56 Da Isoelectric Point: 4.6794
>T144853 WP_000578471.1 NZ_CP046741:c524416-524138 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T144853 NZ_CP062243:3270696-3271160 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10915.28 Da Isoelectric Point: 8.0775
>AT144853 WP_000381186.1 NZ_CP046741:c524697-524413 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKVR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKVR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT144853 NZ_CP062243:3270361-3270696 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|