Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 505732..506310 | Replicon | chromosome |
| Accession | NZ_CP046741 | ||
| Organism | Vibrio cholerae strain 3523-03 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | GPW86_RS02470 | Protein ID | WP_184476332.1 |
| Coordinates | 505732..506049 (-) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A366AI09 |
| Locus tag | GPW86_RS02475 | Protein ID | WP_000557291.1 |
| Coordinates | 506068..506310 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPW86_RS02410 | 500866..501339 | + | 474 | WP_061059125.1 | hypothetical protein | - |
| GPW86_RS02415 | 501336..501446 | + | 111 | WP_079856448.1 | DUF3265 domain-containing protein | - |
| GPW86_RS02420 | 501632..501814 | + | 183 | WP_000947519.1 | DUF645 family protein | - |
| GPW86_RS02430 | 502015..502503 | + | 489 | WP_123011625.1 | hypothetical protein | - |
| GPW86_RS02435 | 502801..502980 | + | 180 | WP_123011626.1 | DUF645 family protein | - |
| GPW86_RS02440 | 503216..503386 | + | 171 | WP_001080654.1 | hypothetical protein | - |
| GPW86_RS02445 | 503386..503787 | + | 402 | WP_000351249.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| GPW86_RS02450 | 503757..503900 | + | 144 | WP_075042602.1 | DUF3265 domain-containing protein | - |
| GPW86_RS02455 | 504089..504268 | + | 180 | Protein_471 | DUF645 family protein | - |
| GPW86_RS02460 | 504555..504833 | + | 279 | WP_033932156.1 | DUF3709 domain-containing protein | - |
| GPW86_RS02465 | 505109..505597 | + | 489 | WP_000424237.1 | hypothetical protein | - |
| GPW86_RS02470 | 505732..506049 | - | 318 | WP_184476332.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPW86_RS02475 | 506068..506310 | - | 243 | WP_000557291.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GPW86_RS02480 | 506553..506978 | + | 426 | WP_061051384.1 | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | - |
| GPW86_RS02485 | 507078..507680 | + | 603 | WP_123011827.1 | hypothetical protein | - |
| GPW86_RS02490 | 508456..509295 | + | 840 | WP_162908513.1 | fructose 1,6-bisphosphatase | - |
| GPW86_RS02495 | 509434..510069 | + | 636 | WP_000691786.1 | DUF2807 domain-containing protein | - |
| GPW86_RS02500 | 510174..510776 | + | 603 | WP_123011827.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 443489..637173 | 193684 | |
| - | inside | Integron | - | - | 444653..571022 | 126369 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12288.14 Da Isoelectric Point: 9.7641
>T144852 WP_184476332.1 NZ_CP046741:c506049-505732 [Vibrio cholerae]
MQSKQYKLSQLAQEHLLKIRHYTIENFAEAQWQKYKSTLLSGFQTLADNPRLGKSCEDIYQNGFYFPVGKHMVYYTKEAD
FILIVAVLGQSQLPQKHLKQSRFVS
MQSKQYKLSQLAQEHLLKIRHYTIENFAEAQWQKYKSTLLSGFQTLADNPRLGKSCEDIYQNGFYFPVGKHMVYYTKEAD
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T144852 NZ_CP062243:c3227814-3227500 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8931.22 Da Isoelectric Point: 5.6630
>AT144852 WP_000557291.1 NZ_CP046741:c506310-506068 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGAAFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGAAFLNTL
Download Length: 243 bp
>AT144852 NZ_CP062243:c3227503-3227087 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|