Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc(toxin) |
| Location | 503216..503787 | Replicon | chromosome |
| Accession | NZ_CP046741 | ||
| Organism | Vibrio cholerae strain 3523-03 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A1T4SJW3 |
| Locus tag | GPW86_RS02445 | Protein ID | WP_000351249.1 |
| Coordinates | 503386..503787 (+) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q8GNG3 |
| Locus tag | GPW86_RS02440 | Protein ID | WP_001080654.1 |
| Coordinates | 503216..503386 (+) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPW86_RS02380 | 498615..498851 | - | 237 | WP_000772125.1 | RNA-binding protein | - |
| GPW86_RS02385 | 499263..499445 | + | 183 | WP_000947519.1 | DUF645 family protein | - |
| GPW86_RS19350 | 499643..500095 | + | 453 | WP_123011672.1 | hypothetical protein | - |
| GPW86_RS02405 | 500239..500727 | + | 489 | WP_000424237.1 | hypothetical protein | - |
| GPW86_RS02410 | 500866..501339 | + | 474 | WP_061059125.1 | hypothetical protein | - |
| GPW86_RS02415 | 501336..501446 | + | 111 | WP_079856448.1 | DUF3265 domain-containing protein | - |
| GPW86_RS02420 | 501632..501814 | + | 183 | WP_000947519.1 | DUF645 family protein | - |
| GPW86_RS02430 | 502015..502503 | + | 489 | WP_123011625.1 | hypothetical protein | - |
| GPW86_RS02435 | 502801..502980 | + | 180 | WP_123011626.1 | DUF645 family protein | - |
| GPW86_RS02440 | 503216..503386 | + | 171 | WP_001080654.1 | hypothetical protein | Antitoxin |
| GPW86_RS02445 | 503386..503787 | + | 402 | WP_000351249.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| GPW86_RS02450 | 503757..503900 | + | 144 | WP_075042602.1 | DUF3265 domain-containing protein | - |
| GPW86_RS02455 | 504089..504268 | + | 180 | Protein_471 | DUF645 family protein | - |
| GPW86_RS02460 | 504555..504833 | + | 279 | WP_033932156.1 | DUF3709 domain-containing protein | - |
| GPW86_RS02465 | 505109..505597 | + | 489 | WP_000424237.1 | hypothetical protein | - |
| GPW86_RS02470 | 505732..506049 | - | 318 | WP_184476332.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPW86_RS02475 | 506068..506310 | - | 243 | WP_000557291.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GPW86_RS02480 | 506553..506978 | + | 426 | WP_061051384.1 | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | - |
| GPW86_RS02485 | 507078..507680 | + | 603 | WP_123011827.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 443489..637173 | 193684 | |
| - | inside | Integron | - | - | 444653..571022 | 126369 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14636.77 Da Isoelectric Point: 4.0128
>T144851 WP_000351249.1 NZ_CP046741:503386-503787 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSVL
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSVL
Download Length: 402 bp
>T144851 NZ_CP062243:c3161903-3161607 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6287.35 Da Isoelectric Point: 10.7274
>AT144851 WP_001080654.1 NZ_CP046741:503216-503386 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
Download Length: 171 bp
>AT144851 NZ_CP062243:c3161605-3161210 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1T4SJW3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1T4SJJ1 |