Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 34862..35400 | Replicon | chromosome |
| Accession | NZ_CP046739 | ||
| Organism | Vibrio cholerae strain 3566-06 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q9KMJ0 |
| Locus tag | GPW70_RS00295 | Protein ID | WP_000802136.1 |
| Coordinates | 35101..35400 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A271VK51 |
| Locus tag | GPW70_RS00290 | Protein ID | WP_001107720.1 |
| Coordinates | 34862..35104 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPW70_RS00250 | 30108..30279 | - | 172 | Protein_44 | DUF645 family protein | - |
| GPW70_RS00255 | 30589..31506 | - | 918 | WP_001887510.1 | alpha/beta hydrolase | - |
| GPW70_RS18945 | 31527..31664 | - | 138 | WP_080482787.1 | superoxide dismutase | - |
| GPW70_RS00260 | 31721..32173 | - | 453 | WP_032473195.1 | hypothetical protein | - |
| GPW70_RS00270 | 32416..32793 | + | 378 | WP_000734783.1 | PEGA domain-containing protein | - |
| GPW70_RS00275 | 32963..33442 | - | 480 | WP_032473214.1 | hypothetical protein | - |
| GPW70_RS00280 | 33578..34012 | - | 435 | WP_043881281.1 | GNAT family N-acetyltransferase | - |
| GPW70_RS00285 | 34170..34652 | - | 483 | WP_032473215.1 | tetratricopeptide repeat protein | - |
| GPW70_RS00290 | 34862..35104 | + | 243 | WP_001107720.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| GPW70_RS00295 | 35101..35400 | + | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPW70_RS00305 | 35517..35993 | - | 477 | WP_019829911.1 | GNAT family N-acetyltransferase | - |
| GPW70_RS00310 | 36189..36968 | - | 780 | WP_001887508.1 | NYN domain-containing protein | - |
| GPW70_RS00315 | 37185..37347 | - | 163 | Protein_56 | DUF645 family protein | - |
| GPW70_RS00325 | 37710..37892 | - | 183 | WP_025987832.1 | DUF645 family protein | - |
| GPW70_RS00330 | 38303..38539 | + | 237 | WP_019830356.1 | RNA recognition motif family protein | - |
| GPW70_RS00335 | 38728..39117 | - | 390 | Protein_59 | VOC family protein | - |
| GPW70_RS00340 | 39849..40002 | - | 154 | Protein_60 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | ugd / htpB / hlyA / hcp-2 / vgrG-2 / vipA/mglA / vipB/mglB / VCA0109 / vasA / vasB / vasC / vasD / vasE / vasF / clpB/vasG / vasH / vasI / vasJ / icmF/vasK / vasL / vgrG-3 / hlyA / zot / ace / zot / ace / cqsA | 39..1050830 | 1050791 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11589.29 Da Isoelectric Point: 9.9232
>T144845 WP_000802136.1 NZ_CP046739:35101-35400 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T144845 NZ_CP062243:c2082946-2082692 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8950.82 Da Isoelectric Point: 4.1677
>AT144845 WP_001107720.1 NZ_CP046739:34862-35104 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT144845 NZ_CP062243:c2083194-2082943 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|