Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /BrnT(toxin) |
| Location | 24964..25462 | Replicon | chromosome |
| Accession | NZ_CP046739 | ||
| Organism | Vibrio cholerae strain 3566-06 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9KMK7 |
| Locus tag | GPW70_RS00210 | Protein ID | WP_000589156.1 |
| Coordinates | 25196..25462 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | Q9KMK6 |
| Locus tag | GPW70_RS00205 | Protein ID | WP_000643598.1 |
| Coordinates | 24964..25209 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPW70_RS00170 | 20489..20944 | - | 456 | WP_001245329.1 | GNAT family N-acetyltransferase | - |
| GPW70_RS00175 | 21071..21502 | - | 432 | WP_044128141.1 | hypothetical protein | - |
| GPW70_RS00180 | 21643..22416 | - | 774 | WP_139284613.1 | hypothetical protein | - |
| GPW70_RS00185 | 22550..23034 | - | 485 | Protein_32 | DUF1993 family protein | - |
| GPW70_RS00190 | 23192..23581 | - | 390 | WP_000491261.1 | VOC family protein | - |
| GPW70_RS00195 | 23785..24237 | - | 453 | WP_032473166.1 | GNAT family N-acetyltransferase | - |
| GPW70_RS00200 | 24404..24820 | - | 417 | WP_019830302.1 | DUF1311 domain-containing protein | - |
| GPW70_RS00205 | 24964..25209 | - | 246 | WP_000643598.1 | hypothetical protein | Antitoxin |
| GPW70_RS00210 | 25196..25462 | - | 267 | WP_000589156.1 | BrnT family toxin | Toxin |
| GPW70_RS00215 | 25770..26003 | - | 234 | WP_032473169.1 | DUF3709 domain-containing protein | - |
| GPW70_RS18940 | 26275..26493 | - | 219 | WP_175470349.1 | hypothetical protein | - |
| GPW70_RS00225 | 27171..27707 | - | 537 | WP_071181460.1 | AAA family ATPase | - |
| GPW70_RS00230 | 27846..28586 | - | 741 | WP_161779866.1 | PhzF family phenazine biosynthesis protein | - |
| GPW70_RS00235 | 28751..29221 | - | 471 | WP_032473170.1 | GNAT family N-acetyltransferase | - |
| GPW70_RS00245 | 29366..29902 | - | 537 | WP_019829934.1 | GNAT family N-acetyltransferase | - |
| GPW70_RS00250 | 30108..30279 | - | 172 | Protein_44 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | ugd / htpB / hlyA / hcp-2 / vgrG-2 / vipA/mglA / vipB/mglB / VCA0109 / vasA / vasB / vasC / vasD / vasE / vasF / clpB/vasG / vasH / vasI / vasJ / icmF/vasK / vasL / vgrG-3 / hlyA / zot / ace / zot / ace / cqsA | 39..1050830 | 1050791 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10092.34 Da Isoelectric Point: 7.3171
>T144844 WP_000589156.1 NZ_CP046739:c25462-25196 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA
Download Length: 267 bp
>T144844 NZ_CP062243:2071050-2071424 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9478.77 Da Isoelectric Point: 6.4832
>AT144844 WP_000643598.1 NZ_CP046739:c25209-24964 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R
Download Length: 246 bp
>AT144844 NZ_CP062243:2070593-2070961 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A271VMP7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A271VME2 |