Detailed information of TA system TA144838

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1004584..1005143
• Replicon: chromosome
• Accession: NZ_CP046738
• Organism: Vibrio cholerae strain 2015V-1126

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPW74_RS17680
• Protein ID: WP_123012084.1
• Coordinates: 1004865..1005143 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9L991
• Locus tag: GPW74_RS17675
• Protein ID: WP_000381183.1
• Coordinates: 1004584..1004868 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPW74_RS17630	999694..999855	-	162	WP_123012082.1	DUF3709 domain-containing protein	-
GPW74_RS17635	999836..999928	-	93	WP_080368416.1	DUF3265 domain-containing protein	-
GPW74_RS18740	999955..1000272	-	318	WP_154401610.1	hypothetical protein	-
GPW74_RS17640	1000286..1000363	-	78	Protein_867	DUF3265 domain-containing protein	-
GPW74_RS17645	1000474..1001304	+	831	WP_000582685.1	hypothetical protein	-
GPW74_RS18745	1001317..1001478	+	162	WP_184478423.1	hypothetical protein	-
GPW74_RS17650	1001770..1002093	-	324	WP_123012139.1	DUF3709 domain-containing protein	-
GPW74_RS17660	1002279..1002719	-	441	WP_001966102.1	DUF1311 domain-containing protein	-
GPW74_RS17665	1002872..1003339	-	468	WP_000702485.1	GNAT family N-acetyltransferase	-
GPW74_RS17675	1004584..1004868	+	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GPW74_RS17680	1004865..1005143	+	279	WP_123012084.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPW74_RS17685	1005302..1005718	-	417	WP_000759008.1	DUF1311 domain-containing protein	-
GPW74_RS17690	1005871..1006122	-	252	WP_123012140.1	TIGR03643 family protein	-
GPW74_RS18750	1006378..1006548	-	171	WP_000934881.1	DUF645 family protein	-
GPW74_RS17705	1006864..1007502	-	639	WP_114743462.1	hypothetical protein	-
GPW74_RS17710	1007529..1007621	-	93	WP_080368416.1	DUF3265 domain-containing protein	-
GPW74_RS17715	1007648..1007986	-	339	WP_000196674.1	hypothetical protein	-
GPW74_RS18755	1008166..1008204	-	39	WP_082798268.1	hypothetical protein	-
GPW74_RS18760	1008258..1008401	-	144	Protein_882	DUF645 family protein	-
GPW74_RS17725	1008786..1008996	-	211	Protein_883	DUF3709 domain-containing protein	-
GPW74_RS17730	1009032..1009157	-	126	WP_123012141.1	DUF3709 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	949375..1072270	122895
	-	inside	Genomic island	blaCARB-7	-	949582..1075528	125946

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10866.57 Da
• Isoelectric Point: 4.6794

>T144838 WP_123012084.1 NZ_CP046738:1004865-1005143 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQRQKFPND

Nucleotide

• Length: 279 bp

>T144838 NZ_CP062243:c1265801-1265694 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10901.25 Da
• Isoelectric Point: 8.0775

>AT144838 WP_000381183.1 NZ_CP046738:1004584-1004868 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Nucleotide

• Length: 285 bp

>AT144838 NZ_CP062243:1265848-1265914 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Antitoxin

• AlphaFold DB: A0A067BL33