Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 979817..980364 Replicon chromosome
Accession NZ_CP046738
Organism Vibrio cholerae strain 2015V-1126

Toxin (Protein)


Gene name relE Uniprot ID A0A0Q0PYS1
Locus tag GPW74_RS17440 Protein ID WP_000229322.1
Coordinates 979817..980119 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag GPW74_RS17445 Protein ID WP_000861987.1
Coordinates 980107..980364 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW74_RS17410 975231..975647 - 417 WP_000759008.1 DUF1311 domain-containing protein -
GPW74_RS17415 975845..976015 - 171 Protein_826 DUF645 family protein -
GPW74_RS17420 976377..976538 - 162 WP_184478421.1 DUF645 family protein -
GPW74_RS17425 976899..977080 - 182 Protein_828 DUF645 family protein -
GPW74_RS17435 977835..979658 - 1824 WP_095459690.1 ATP-binding protein -
GPW74_RS17440 979817..980119 - 303 WP_000229322.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPW74_RS17445 980107..980364 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPW74_RS17450 980559..981095 - 537 WP_000831688.1 hypothetical protein -
GPW74_RS17455 981147..981260 - 114 WP_123012072.1 DUF3265 domain-containing protein -
GPW74_RS17460 981260..981868 - 609 WP_158126473.1 hypothetical protein -
GPW74_RS17465 982053..982499 + 447 WP_033935903.1 BLUF domain-containing protein -
GPW74_RS17470 982748..982981 - 234 WP_032477388.1 DUF3709 domain-containing protein -
GPW74_RS17475 983260..984084 - 825 WP_080281735.1 HNH endonuclease -
GPW74_RS17480 984217..984444 - 228 WP_123012074.1 DUF645 family protein -
GPW74_RS17490 984824..985276 + 453 WP_000024294.1 DUF2384 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 949375..1072270 122895
- inside Genomic island blaCARB-7 - 949582..1075528 125946


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11737.67 Da        Isoelectric Point: 5.1972

>T144837 WP_000229322.1 NZ_CP046738:c980119-979817 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T144837 NZ_CP062243:c1265266-1265159 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT144837 WP_000861987.1 NZ_CP046738:c980364-980107 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT144837 NZ_CP062243:1265313-1265379 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PYS1

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References