Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 964788..965353 | Replicon | chromosome |
| Accession | NZ_CP046738 | ||
| Organism | Vibrio cholerae strain 2015V-1126 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HCW8 |
| Locus tag | GPW74_RS17310 | Protein ID | WP_000869999.1 |
| Coordinates | 964788..965075 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | D0IIK3 |
| Locus tag | GPW74_RS17315 | Protein ID | WP_000086649.1 |
| Coordinates | 965072..965353 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPW74_RS17250 | 960219..960389 | - | 171 | WP_114974226.1 | DUF3709 domain-containing protein | - |
| GPW74_RS17260 | 960659..961240 | - | 582 | WP_114736614.1 | hypothetical protein | - |
| GPW74_RS18700 | 961238..961303 | - | 66 | Protein_799 | nitrate reductase | - |
| GPW74_RS17265 | 961390..961803 | - | 414 | WP_123012064.1 | GNAT family N-acetyltransferase | - |
| GPW74_RS17270 | 962021..962203 | - | 183 | WP_001966054.1 | DUF645 family protein | - |
| GPW74_RS17280 | 962520..962843 | - | 324 | WP_000277233.1 | hypothetical protein | - |
| GPW74_RS17285 | 963009..963524 | - | 516 | WP_123012066.1 | lipocalin family protein | - |
| GPW74_RS17295 | 963672..964085 | - | 414 | WP_000049418.1 | VOC family protein | - |
| GPW74_RS17305 | 964257..964631 | - | 375 | WP_000722184.1 | hypothetical protein | - |
| GPW74_RS17310 | 964788..965075 | - | 288 | WP_000869999.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPW74_RS17315 | 965072..965353 | - | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GPW74_RS17320 | 965554..965820 | - | 267 | WP_080300695.1 | TIGR03643 family protein | - |
| GPW74_RS17325 | 966068..966493 | - | 426 | WP_108347903.1 | hypothetical protein | - |
| GPW74_RS18705 | 966790..967170 | - | 381 | WP_055049814.1 | hypothetical protein | - |
| GPW74_RS17330 | 967401..967763 | - | 363 | WP_162796981.1 | DUF4144 domain-containing protein | - |
| GPW74_RS17335 | 967803..968090 | - | 288 | WP_080314578.1 | DUF645 family protein | - |
| GPW74_RS17340 | 968387..968773 | - | 387 | WP_184478419.1 | VOC family protein | - |
| GPW74_RS17345 | 968922..969377 | - | 456 | WP_001245329.1 | GNAT family N-acetyltransferase | - |
| GPW74_RS17350 | 969563..969943 | - | 381 | WP_148038997.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 949375..1072270 | 122895 | |
| - | inside | Genomic island | blaCARB-7 | - | 949582..1075528 | 125946 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10997.74 Da Isoelectric Point: 6.0710
>T144835 WP_000869999.1 NZ_CP046738:c965075-964788 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T144835 NZ_CP062243:c475764-475546 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10361.93 Da Isoelectric Point: 5.1548
>AT144835 WP_000086649.1 NZ_CP046738:c965353-965072 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
Download Length: 282 bp
>AT144835 NZ_CP062243:c476164-475790 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3AEF1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UIW4 |