144834

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 956056..956566 Replicon chromosome
Accession NZ_CP046738
Organism Vibrio cholerae strain 2015V-1126

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag GPW74_RS17220 Protein ID WP_114805999.1
Coordinates 956056..956319 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag GPW74_RS17225 Protein ID WP_108336324.1
Coordinates 956312..956566 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW74_RS17160 951137..951538 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
GPW74_RS17165 951538..951708 - 171 WP_001080654.1 hypothetical protein -
GPW74_RS17170 951779..951910 - 132 WP_111673665.1 DUF3265 domain-containing protein -
GPW74_RS17175 951886..952422 - 537 WP_000469486.1 GNAT family N-acetyltransferase -
GPW74_RS17180 952572..953372 - 801 WP_085605081.1 PhzF family phenazine biosynthesis protein -
GPW74_RS17185 953532..953903 - 372 WP_001164077.1 nucleotide pyrophosphohydrolase -
GPW74_RS17190 954045..954566 - 522 WP_000921691.1 DUF2442 domain-containing protein -
GPW74_RS17195 954560..954829 - 270 WP_001114075.1 DUF4160 domain-containing protein -
GPW74_RS17205 955130..955411 - 282 WP_114794440.1 DUF1289 domain-containing protein -
GPW74_RS17210 955590..955685 - 96 WP_001907607.1 DUF645 family protein -
GPW74_RS17215 955926..956060 - 135 Protein_790 DUF3265 domain-containing protein -
GPW74_RS17220 956056..956319 - 264 WP_114805999.1 Txe/YoeB family addiction module toxin Toxin
GPW74_RS17225 956312..956566 - 255 WP_108336324.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GPW74_RS17230 956775..957488 - 714 WP_000123659.1 Fic family protein -
GPW74_RS17235 957694..958065 - 372 WP_057552189.1 hypothetical protein -
GPW74_RS18695 958294..958389 - 96 WP_001907607.1 DUF645 family protein -
GPW74_RS17245 958854..959840 + 987 WP_001170909.1 sulfate ABC transporter substrate-binding protein -
GPW74_RS17250 960219..960389 - 171 WP_114974226.1 DUF3709 domain-containing protein -
GPW74_RS17260 960659..961240 - 582 WP_114736614.1 hypothetical protein -
GPW74_RS18700 961238..961303 - 66 Protein_799 nitrate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 949375..1072270 122895
- inside Genomic island blaCARB-7 - 949582..1075528 125946


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10419.75 Da        Isoelectric Point: 7.9816

>T144834 WP_114805999.1 NZ_CP046738:c956319-956056 [Vibrio cholerae]
MSSRLLSWTDESWDDYLYWQTQDKKTLKRINKIINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDNAMTV
ISCRYHY

Download         Length: 264 bp

>T144834 NZ_CP062243:c259380-259039 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9491.78 Da        Isoelectric Point: 5.0623

>AT144834 WP_108336324.1 NZ_CP046738:c956566-956312 [Vibrio cholerae]
MRIVSFTEARNSLKAVLDAVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANVEHLNRSIAQFKAGKVIQRE
LIDE

Download         Length: 255 bp

>AT144834 NZ_CP062243:c259718-259401 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References