Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 954045..954829 Replicon chromosome
Accession NZ_CP046738
Organism Vibrio cholerae strain 2015V-1126

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag GPW74_RS17195 Protein ID WP_001114075.1
Coordinates 954560..954829 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag GPW74_RS17190 Protein ID WP_000921691.1
Coordinates 954045..954566 (-) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW74_RS17145 949582..950034 + 453 WP_000024295.1 DUF2384 domain-containing protein -
GPW74_RS17150 950034..950504 + 471 WP_085605075.1 RES family NAD+ phosphorylase -
GPW74_RS17155 950648..950989 - 342 WP_085605078.1 aldehyde-activating protein -
GPW74_RS17160 951137..951538 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
GPW74_RS17165 951538..951708 - 171 WP_001080654.1 hypothetical protein -
GPW74_RS17170 951779..951910 - 132 WP_111673665.1 DUF3265 domain-containing protein -
GPW74_RS17175 951886..952422 - 537 WP_000469486.1 GNAT family N-acetyltransferase -
GPW74_RS17180 952572..953372 - 801 WP_085605081.1 PhzF family phenazine biosynthesis protein -
GPW74_RS17185 953532..953903 - 372 WP_001164077.1 nucleotide pyrophosphohydrolase -
GPW74_RS17190 954045..954566 - 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
GPW74_RS17195 954560..954829 - 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
GPW74_RS17205 955130..955411 - 282 WP_114794440.1 DUF1289 domain-containing protein -
GPW74_RS17210 955590..955685 - 96 WP_001907607.1 DUF645 family protein -
GPW74_RS17215 955926..956060 - 135 Protein_790 DUF3265 domain-containing protein -
GPW74_RS17220 956056..956319 - 264 WP_114805999.1 Txe/YoeB family addiction module toxin -
GPW74_RS17225 956312..956566 - 255 WP_108336324.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
GPW74_RS17230 956775..957488 - 714 WP_000123659.1 Fic family protein -
GPW74_RS17235 957694..958065 - 372 WP_057552189.1 hypothetical protein -
GPW74_RS18695 958294..958389 - 96 WP_001907607.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 949375..1072270 122895
- inside Genomic island blaCARB-7 - 949582..1075528 125946


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T144833 WP_001114075.1 NZ_CP046738:c954829-954560 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T144833 NZ_CP062243:248788-249186 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT144833 WP_000921691.1 NZ_CP046738:c954566-954045 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT144833 NZ_CP062243:248492-248785 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References