144832

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 951137..951708 Replicon chromosome
Accession NZ_CP046738
Organism Vibrio cholerae strain 2015V-1126

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag GPW74_RS17160 Protein ID WP_000351248.1
Coordinates 951137..951538 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag GPW74_RS17165 Protein ID WP_001080654.1
Coordinates 951538..951708 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW74_RS17120 946604..947218 - 615 WP_000675194.1 OmpA family protein -
GPW74_RS17125 947440..947913 + 474 WP_000034756.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
GPW74_RS17130 947991..948425 - 435 WP_123012136.1 IS200/IS605 family transposase -
GPW74_RS18690 948411..948543 - 133 Protein_775 IS200/IS605 family transposase -
GPW74_RS17135 948884..949360 - 477 Protein_776 GNAT family N-acetyltransferase -
GPW74_RS17145 949582..950034 + 453 WP_000024295.1 DUF2384 domain-containing protein -
GPW74_RS17150 950034..950504 + 471 WP_085605075.1 RES family NAD+ phosphorylase -
GPW74_RS17155 950648..950989 - 342 WP_085605078.1 aldehyde-activating protein -
GPW74_RS17160 951137..951538 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GPW74_RS17165 951538..951708 - 171 WP_001080654.1 hypothetical protein Antitoxin
GPW74_RS17170 951779..951910 - 132 WP_111673665.1 DUF3265 domain-containing protein -
GPW74_RS17175 951886..952422 - 537 WP_000469486.1 GNAT family N-acetyltransferase -
GPW74_RS17180 952572..953372 - 801 WP_085605081.1 PhzF family phenazine biosynthesis protein -
GPW74_RS17185 953532..953903 - 372 WP_001164077.1 nucleotide pyrophosphohydrolase -
GPW74_RS17190 954045..954566 - 522 WP_000921691.1 DUF2442 domain-containing protein -
GPW74_RS17195 954560..954829 - 270 WP_001114075.1 DUF4160 domain-containing protein -
GPW74_RS17205 955130..955411 - 282 WP_114794440.1 DUF1289 domain-containing protein -
GPW74_RS17210 955590..955685 - 96 WP_001907607.1 DUF645 family protein -
GPW74_RS17215 955926..956060 - 135 Protein_790 DUF3265 domain-containing protein -
GPW74_RS17220 956056..956319 - 264 WP_114805999.1 Txe/YoeB family addiction module toxin -
GPW74_RS17225 956312..956566 - 255 WP_108336324.1 type II toxin-antitoxin system prevent-host-death family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 947991..948449 458
- inside Integron - - 949375..1072270 122895
- inside Genomic island blaCARB-7 - 949582..1075528 125946


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T144832 WP_000351248.1 NZ_CP046738:c951538-951137 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T144832 NZ_CP062243:c242726-242448 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT144832 WP_001080654.1 NZ_CP046738:c951708-951538 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT144832 NZ_CP062243:c242989-242729 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References