Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/Doc(toxin) |
Location | 951137..951708 | Replicon | chromosome |
Accession | NZ_CP046738 | ||
Organism | Vibrio cholerae strain 2015V-1126 |
Toxin (Protein)
Gene name | doc | Uniprot ID | Q9KMA2 |
Locus tag | GPW74_RS17160 | Protein ID | WP_000351248.1 |
Coordinates | 951137..951538 (-) | Length | 134 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | Q8GNG3 |
Locus tag | GPW74_RS17165 | Protein ID | WP_001080654.1 |
Coordinates | 951538..951708 (-) | Length | 57 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GPW74_RS17120 | 946604..947218 | - | 615 | WP_000675194.1 | OmpA family protein | - |
GPW74_RS17125 | 947440..947913 | + | 474 | WP_000034756.1 | FKBP-type peptidyl-prolyl cis-trans isomerase | - |
GPW74_RS17130 | 947991..948425 | - | 435 | WP_123012136.1 | IS200/IS605 family transposase | - |
GPW74_RS18690 | 948411..948543 | - | 133 | Protein_775 | IS200/IS605 family transposase | - |
GPW74_RS17135 | 948884..949360 | - | 477 | Protein_776 | GNAT family N-acetyltransferase | - |
GPW74_RS17145 | 949582..950034 | + | 453 | WP_000024295.1 | DUF2384 domain-containing protein | - |
GPW74_RS17150 | 950034..950504 | + | 471 | WP_085605075.1 | RES family NAD+ phosphorylase | - |
GPW74_RS17155 | 950648..950989 | - | 342 | WP_085605078.1 | aldehyde-activating protein | - |
GPW74_RS17160 | 951137..951538 | - | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
GPW74_RS17165 | 951538..951708 | - | 171 | WP_001080654.1 | hypothetical protein | Antitoxin |
GPW74_RS17170 | 951779..951910 | - | 132 | WP_111673665.1 | DUF3265 domain-containing protein | - |
GPW74_RS17175 | 951886..952422 | - | 537 | WP_000469486.1 | GNAT family N-acetyltransferase | - |
GPW74_RS17180 | 952572..953372 | - | 801 | WP_085605081.1 | PhzF family phenazine biosynthesis protein | - |
GPW74_RS17185 | 953532..953903 | - | 372 | WP_001164077.1 | nucleotide pyrophosphohydrolase | - |
GPW74_RS17190 | 954045..954566 | - | 522 | WP_000921691.1 | DUF2442 domain-containing protein | - |
GPW74_RS17195 | 954560..954829 | - | 270 | WP_001114075.1 | DUF4160 domain-containing protein | - |
GPW74_RS17205 | 955130..955411 | - | 282 | WP_114794440.1 | DUF1289 domain-containing protein | - |
GPW74_RS17210 | 955590..955685 | - | 96 | WP_001907607.1 | DUF645 family protein | - |
GPW74_RS17215 | 955926..956060 | - | 135 | Protein_790 | DUF3265 domain-containing protein | - |
GPW74_RS17220 | 956056..956319 | - | 264 | WP_114805999.1 | Txe/YoeB family addiction module toxin | - |
GPW74_RS17225 | 956312..956566 | - | 255 | WP_108336324.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 947991..948449 | 458 | |
- | inside | Integron | - | - | 949375..1072270 | 122895 | |
- | inside | Genomic island | blaCARB-7 | - | 949582..1075528 | 125946 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14608.71 Da Isoelectric Point: 4.0128
>T144832 WP_000351248.1 NZ_CP046738:c951538-951137 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
Download Length: 402 bp
>T144832 NZ_CP062243:c242726-242448 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6287.35 Da Isoelectric Point: 10.7274
>AT144832 WP_001080654.1 NZ_CP046738:c951708-951538 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
Download Length: 171 bp
>AT144832 NZ_CP062243:c242989-242729 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Q0PN34 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1T4SJJ1 |