Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 18998..20823 Replicon chromosome
Accession NZ_CP046737
Organism Vibrio cholerae strain 2015V-1126

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GPW74_RS00075 Protein ID WP_184478447.1
Coordinates 19462..20823 (-) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GPW74_RS00070 Protein ID WP_032472658.1
Coordinates 18998..19465 (-) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW74_RS00065 15409..18681 + 3273 WP_123012155.1 type I restriction endonuclease subunit R -
GPW74_RS00070 18998..19465 - 468 WP_032472658.1 helix-turn-helix domain-containing protein Antitoxin
GPW74_RS00075 19462..20823 - 1362 WP_184478447.1 type II toxin-antitoxin system HipA family toxin Toxin
GPW74_RS00090 21619..22104 - 486 WP_000162689.1 SsrA-binding protein SmpB -
GPW74_RS00095 22288..22722 + 435 WP_000815880.1 type II toxin-antitoxin system RatA family toxin -
GPW74_RS00100 22725..23030 + 306 WP_001918351.1 RnfH family protein -
GPW74_RS00105 23108..23467 - 360 WP_001160907.1 outer membrane protein assembly factor BamE -
GPW74_RS00110 23626..25290 - 1665 WP_057552513.1 DNA repair protein RecN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-386)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51395.23 Da        Isoelectric Point: 4.8090

>T144831 WP_184478447.1 NZ_CP046737:c20823-19462 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFFFDDMDKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFAGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

>T144831 NZ_CP062242:c4569657-4569316 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17073.60 Da        Isoelectric Point: 10.7084

>AT144831 WP_032472658.1 NZ_CP046737:c19465-18998 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKNATHSIKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Download         Length: 468 bp

>AT144831 NZ_CP062242:4569652-4569728 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References