Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2915228..2917053 Replicon chromosome
Accession NZ_CP046736
Organism Vibrio cholerae strain 3528-08

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GPW66_RS18250 Protein ID WP_032472659.1
Coordinates 2915228..2916589 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GPW66_RS18255 Protein ID WP_032472658.1
Coordinates 2916586..2917053 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW66_RS18215 2910275..2910703 + 429 WP_019830040.1 DUF2787 domain-containing protein -
GPW66_RS18220 2910754..2911200 + 447 WP_019830041.1 DUF2787 domain-containing protein -
GPW66_RS18225 2911303..2911830 + 528 WP_019830042.1 Flp pilus assembly complex ATPase component TadA -
GPW66_RS18230 2911930..2912289 + 360 WP_134983340.1 hypothetical protein -
GPW66_RS18235 2912322..2912962 - 641 Protein_2551 inovirus Gp2 family protein -
GPW66_RS18240 2914411..2914611 - 201 WP_019830047.1 AlpA family transcriptional regulator -
GPW66_RS18250 2915228..2916589 + 1362 WP_032472659.1 type II toxin-antitoxin system HipA family toxin Toxin
GPW66_RS18255 2916586..2917053 + 468 WP_032472658.1 helix-turn-helix domain-containing protein Antitoxin
GPW66_RS18260 2917481..2918059 + 579 WP_000109982.1 class I SAM-dependent methyltransferase -
GPW66_RS18265 2918063..2920999 + 2937 WP_032472657.1 DEAD/DEAH box helicase family protein -
GPW66_RS18270 2921070..2922019 + 950 Protein_2557 NERD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-383)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51377.35 Da        Isoelectric Point: 5.0463

>T144830 WP_032472659.1 NZ_CP046736:2915228-2916589 [Vibrio cholerae]
MEELTVQAFIRGQWIDIGIISFPKSSQHNFRVTELNYLSDYALKHYDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWELL

Download         Length: 1362 bp

>T144830 NZ_CP062242:c4523870-4523613 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17073.60 Da        Isoelectric Point: 10.7084

>AT144830 WP_032472658.1 NZ_CP046736:2916586-2917053 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKNATHSIKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Download         Length: 468 bp

>AT144830 NZ_CP062242:c4523601-4523056 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References