Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 1020039..1020604 | Replicon | chromosome |
| Accession | NZ_CP046735 | ||
| Organism | Vibrio cholerae strain 3528-08 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HCW8 |
| Locus tag | GPW66_RS04605 | Protein ID | WP_000869999.1 |
| Coordinates | 1020039..1020326 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | D0IIK3 |
| Locus tag | GPW66_RS04610 | Protein ID | WP_000086649.1 |
| Coordinates | 1020323..1020604 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPW66_RS04575 | 1015226..1016362 | - | 1137 | WP_001961932.1 | hypothetical protein | - |
| GPW66_RS04580 | 1016359..1016859 | - | 501 | WP_032468121.1 | DUF4365 domain-containing protein | - |
| GPW66_RS04585 | 1017056..1017715 | - | 660 | WP_113604415.1 | Bax inhibitor-1 family protein | - |
| GPW66_RS04590 | 1017863..1019170 | - | 1308 | WP_158106267.1 | DUF3644 domain-containing protein | - |
| GPW66_RS04595 | 1019370..1019618 | + | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GPW66_RS04600 | 1019608..1019898 | + | 291 | WP_113604414.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPW66_RS04605 | 1020039..1020326 | - | 288 | WP_000869999.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPW66_RS04610 | 1020323..1020604 | - | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GPW66_RS04615 | 1020865..1021110 | + | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| GPW66_RS04620 | 1021110..1021427 | + | 318 | WP_000077449.1 | CcdB family protein | - |
| GPW66_RS04625 | 1021604..1021786 | - | 183 | WP_071180846.1 | DUF645 family protein | - |
| GPW66_RS04630 | 1022012..1022461 | - | 450 | WP_158106268.1 | GyrI-like domain-containing protein | - |
| GPW66_RS04635 | 1022617..1022832 | - | 216 | WP_123011644.1 | hypothetical protein | - |
| GPW66_RS04640 | 1022829..1023080 | - | 252 | WP_123011643.1 | hypothetical protein | - |
| GPW66_RS04645 | 1023317..1023589 | + | 273 | WP_000246254.1 | DUF1778 domain-containing protein | - |
| GPW66_RS04650 | 1023586..1024083 | + | 498 | WP_095475303.1 | GNAT family N-acetyltransferase | - |
| GPW66_RS04655 | 1024116..1024205 | - | 90 | WP_072615218.1 | DUF3265 domain-containing protein | - |
| GPW66_RS04660 | 1024223..1024834 | - | 612 | WP_009387497.1 | hypothetical protein | - |
| GPW66_RS04675 | 1025080..1025361 | - | 282 | WP_002023460.1 | DUF1289 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 990327..1025301 | 34974 | |
| - | inside | Integron | - | hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA | 2..1025486 | 1025484 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10997.74 Da Isoelectric Point: 6.0710
>T144829 WP_000869999.1 NZ_CP046735:c1020326-1020039 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T144829 NZ_CP062242:4438509-4438859 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10361.93 Da Isoelectric Point: 5.1548
>AT144829 WP_000086649.1 NZ_CP046735:c1020604-1020323 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
Download Length: 282 bp
>AT144829 NZ_CP062242:4438264-4438515 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3AEF1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UIW4 |