Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1730560..1732177 Replicon plasmid pLLRS-1
Accession NZ_CP046730
Organism Ralstonia syzygii strain LLRS-1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GO998_RS23950 Protein ID WP_211905427.1
Coordinates 1730560..1731906 (-) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GO998_RS23955 Protein ID WP_013210321.1
Coordinates 1731911..1732177 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GO998_RS23925 1725927..1726073 + 147 WP_211905422.1 hypothetical protein -
GO998_RS23930 (GO998_23905) 1726206..1726832 - 627 WP_211905423.1 FMN-dependent NADH-azoreductase -
GO998_RS23935 (GO998_23910) 1726972..1727922 + 951 WP_211905424.1 LysR family transcriptional regulator -
GO998_RS23940 (GO998_23915) 1728015..1729583 + 1569 WP_211905425.1 MDR family MFS transporter -
GO998_RS23945 (GO998_23920) 1729587..1730483 - 897 WP_211905426.1 oxygenase MpaB family protein -
GO998_RS23950 (GO998_23925) 1730560..1731906 - 1347 WP_211905427.1 type II toxin-antitoxin system HipA family toxin Toxin
GO998_RS23955 (GO998_23930) 1731911..1732177 - 267 WP_013210321.1 helix-turn-helix transcriptional regulator Antitoxin
GO998_RS23960 (GO998_23935) 1732373..1733278 + 906 WP_048817081.1 hypothetical protein -
GO998_RS23965 (GO998_23940) 1733294..1733737 - 444 WP_172840169.1 PGDYG domain-containing protein -
GO998_RS23970 (GO998_23945) 1733977..1734360 + 384 WP_075468668.1 VOC family protein -
GO998_RS23975 (GO998_23950) 1734387..1735505 - 1119 WP_211905428.1 peptidase -
GO998_RS23980 (GO998_23955) 1735508..1736347 - 840 WP_211905429.1 AraC family transcriptional regulator -
GO998_RS23985 (GO998_23960) 1736450..1736926 - 477 WP_211905430.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - acrB / fliI / fliG / fliM / flgG / flgC / cyaB / cheY / motA / cheW / cheB / cheY / adeG 1..2046405 2046405


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(11-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 49675.06 Da        Isoelectric Point: 7.5731

>T144824 WP_211905427.1 NZ_CP046730:c1731906-1730560 [Ralstonia syzygii]
MGRRSHTRALGLWMNGTHVGHWELPPHQGDVLKYAASWVAAPEGRPLSLSLPFTPDNAPYKGPAVRAYFENLLPDSRDIR
ERIARRFQAGTTEAFDLLEQIGRDCIGALQVLPADMAPAGIGDIDAEPLTEAQIAQTLRETVAPPPLGGMPEDDGNFRIS
IAGAQEKTAFLQIDGRWYRPRGATPTSHIFKLPMGRVGNMKLDLSESVENEWLCSLVLRAYGLPIAHCRPLVFEDQKVLA
VERFDRMWRDHRGRQLIRLPQEDMCQATATPPHLKYEADGGPGIDRIMGLLDGSARRDADLLMLFQSQVLFWMLCAPDGH
AKNFSLALRPGGAYALTPLYDVMSAYPLLGEGPGKLSPHRIRLAMAVRSKNPHWKMQDVQRRHWLGLGQRHGIVTPEGGH
AAAIVDSLVARTPEVIRTVRALLPEDFPQPLADRILRGLQSAADRLAE

Download         Length: 1347 bp

>T144824 NZ_CP062242:c3161903-3161607 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9743.27 Da        Isoelectric Point: 11.3495

>AT144824 WP_013210321.1 NZ_CP046730:c1732177-1731911 [Ralstonia syzygii]
MNEFIVRTPEQLPAILKGFRKQAGLSQAELAARMGMRQQTLSALERNAENVSAGRLMRLLSVLGVELVLRKPDASGERGR
PASDQPQW

Download         Length: 267 bp

>AT144824 NZ_CP062242:c3161605-3161210 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References