Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 2223733..2224321 Replicon chromosome
Accession NZ_CP046729
Organism Ralstonia syzygii strain LLRS-1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag GO998_RS10330 Protein ID WP_134927452.1
Coordinates 2223733..2224041 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GO998_RS10335 Protein ID WP_013212794.1
Coordinates 2224034..2224321 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GO998_RS10310 (GO998_10315) 2219889..2220806 - 918 WP_075464683.1 sugar ABC transporter substrate-binding protein -
GO998_RS10315 (GO998_10320) 2221032..2222084 - 1053 WP_211903611.1 LacI family DNA-binding transcriptional regulator -
GO998_RS10320 (GO998_10325) 2222220..2223377 + 1158 WP_211903612.1 fatty acid desaturase family protein -
GO998_RS10325 (GO998_10330) 2223343..2223654 + 312 WP_075464689.1 Rieske 2Fe-2S domain-containing protein -
GO998_RS10330 (GO998_10335) 2223733..2224041 + 309 WP_134927452.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GO998_RS10335 (GO998_10340) 2224034..2224321 + 288 WP_013212794.1 putative addiction module antidote protein Antitoxin
GO998_RS10340 (GO998_10345) 2224334..2225179 - 846 WP_075464693.1 TIM barrel protein -
GO998_RS10345 (GO998_10350) 2225176..2226213 - 1038 WP_211903613.1 xylose isomerase -
GO998_RS10350 (GO998_10355) 2226210..2227499 - 1290 WP_211903614.1 FAD-dependent oxidoreductase -
GO998_RS10355 (GO998_10360) 2227666..2228583 + 918 WP_075464699.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(6-91)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11448.09 Da        Isoelectric Point: 10.2647

>T144821 WP_134927452.1 NZ_CP046729:2223733-2224041 [Ralstonia syzygii]
MHTLIRSDTFDRWLEKLRDKRAKARIAARLVSASFGNFGDCKPVGEGVSEMRIDVGAGYRVYYTRQGTVVYILLTGGNKA
TQAQDIKQAIRMARDLKESGHD

Download         Length: 309 bp

>T144821 NZ_CP062242:2770812-2771141 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10022.45 Da        Isoelectric Point: 4.7361

>AT144821 WP_013212794.1 NZ_CP046729:2224034-2224321 [Ralstonia syzygii]
MTETYAPFDAAAYLDSEETIAEFLAAAMEDPNPDVFLAALGAVARARGIAKVAADAGLGRESLYKAISPGAHPRYETIQK
IMRALGVRLNVTPAA

Download         Length: 288 bp

>AT144821 NZ_CP062242:2770474-2770791 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References