Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3773951..3774480 Replicon chromosome
Accession NZ_CP046728
Organism Mycobacterium tuberculosis strain TCDC11

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag GP477_RS17635 Protein ID WP_003417760.1
Coordinates 3774223..3774480 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag GP477_RS17630 Protein ID WP_003417757.1
Coordinates 3773951..3774226 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GP477_RS17595 3770524..3771318 - 795 WP_003417738.1 BBE domain-containing protein -
GP477_RS17600 3771400..3771771 - 372 WP_003417739.1 FAD-binding oxidoreductase -
GP477_RS17605 3771669..3771887 - 219 WP_157132559.1 hypothetical protein -
GP477_RS17610 3771914..3772174 - 261 WP_003417741.1 hypothetical protein -
GP477_RS17615 3772289..3772678 + 390 WP_003417745.1 DUF732 domain-containing protein -
GP477_RS17620 3772692..3772985 - 294 WP_003417749.1 DUF3017 domain-containing protein -
GP477_RS17625 3772982..3773827 - 846 WP_175285387.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
GP477_RS17630 3773951..3774226 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
GP477_RS17635 3774223..3774480 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
GP477_RS17640 3774522..3775712 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
GP477_RS17645 3775829..3776197 + 369 WP_003417765.1 FHA domain-containing protein -
GP477_RS17650 3776194..3776745 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
GP477_RS17655 3776752..3777333 - 582 WP_003417769.1 ATP/GTP-binding protein -
GP477_RS17660 3777314..3777682 - 369 WP_003417772.1 DUF742 domain-containing protein -
GP477_RS17665 3777660..3778052 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T144818 WP_003417760.1 NZ_CP046728:3774223-3774480 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T144818 NZ_CP062242:c2082946-2082692 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT144818 WP_003417757.1 NZ_CP046728:3773951-3774226 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT144818 NZ_CP062242:c2083194-2082943 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References