Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2926101..2926815 Replicon chromosome
Accession NZ_CP046728
Organism Mycobacterium tuberculosis strain TCDC11

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag GP477_RS13630 Protein ID WP_003413460.1
Coordinates 2926375..2926815 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag GP477_RS13625 Protein ID WP_003413456.1
Coordinates 2926101..2926388 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GP477_RS13590 2921523..2921768 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
GP477_RS13595 2921765..2922169 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
GP477_RS13600 2922386..2923006 + 621 WP_003413441.1 DUF4178 domain-containing protein -
GP477_RS13605 2923017..2923511 + 495 WP_003413444.1 DUF2617 family protein -
GP477_RS13610 2923508..2923939 + 432 WP_003899390.1 DUF4247 domain-containing protein -
GP477_RS13615 2924021..2924422 + 402 WP_003899391.1 DUF350 domain-containing protein -
GP477_RS13620 2924419..2925990 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
GP477_RS13625 2926101..2926388 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
GP477_RS13630 2926375..2926815 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
GP477_RS13635 2926836..2927591 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
GP477_RS13640 2927724..2928320 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
GP477_RS13645 2928328..2929173 - 846 WP_003413466.1 acyl-CoA thioesterase II -
GP477_RS13650 2929202..2930101 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
GP477_RS13655 2930229..2930903 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T144807 WP_003413460.1 NZ_CP046728:2926375-2926815 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T144807 NZ_CP062242:c259380-259039 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT144807 WP_003413456.1 NZ_CP046728:2926101-2926388 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT144807 NZ_CP062242:c259718-259401 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References