Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2401832..2402361 Replicon chromosome
Accession NZ_CP046728
Organism Mycobacterium tuberculosis strain TCDC11

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag GP477_RS11160 Protein ID WP_003411124.1
Coordinates 2401832..2402149 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag GP477_RS11165 Protein ID WP_003411127.1
Coordinates 2402146..2402361 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GP477_RS11130 2396853..2397929 + 1077 WP_003411110.1 hypothetical protein -
GP477_RS11135 2397926..2398207 + 282 WP_003411112.1 hypothetical protein -
GP477_RS11140 2398243..2399316 + 1074 WP_003901338.1 quinone-dependent dihydroorotate dehydrogenase -
GP477_RS11145 2399321..2399851 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
GP477_RS11150 2399899..2401245 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
GP477_RS11160 2401832..2402149 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GP477_RS11165 2402146..2402361 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
GP477_RS11170 2402616..2403674 + 1059 WP_003411129.1 hypothetical protein -
GP477_RS11175 2403804..2404160 - 357 WP_003411130.1 hypothetical protein -
GP477_RS11180 2404255..2405037 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
GP477_RS11185 2405305..2405595 - 291 WP_003900476.1 YggT family protein -
GP477_RS11190 2405757..2406413 - 657 WP_003411133.1 cell division protein SepF -
GP477_RS11195 2406475..2407254 - 780 WP_015575160.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T144801 WP_003411124.1 NZ_CP046728:c2402149-2401832 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T144801 NZ_CP062241:4343924-4344097 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT144801 WP_003411127.1 NZ_CP046728:c2402361-2402146 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT144801 NZ_CP062241:4343600-4343896 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References