Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2360837..2361532 Replicon chromosome
Accession NZ_CP046728
Organism Mycobacterium tuberculosis strain TCDC11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GP477_RS10945 Protein ID WP_003905754.1
Coordinates 2360837..2361271 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag GP477_RS10950 Protein ID WP_003410814.1
Coordinates 2361278..2361532 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GP477_RS10935 2356991..2360032 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
GP477_RS10940 2360142..2360858 + 717 WP_003410793.1 SWIM zinc finger family protein -
GP477_RS10945 2360837..2361271 - 435 WP_003905754.1 type II toxin-antitoxin system VapC family toxin Toxin
GP477_RS10950 2361278..2361532 - 255 WP_003410814.1 antitoxin Antitoxin
GP477_RS10955 2361548..2361805 - 258 WP_003410816.1 hypothetical protein -
GP477_RS10960 2362339..2363600 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
GP477_RS10965 2364110..2364406 + 297 WP_003410820.1 PE family protein -
GP477_RS10975 2365821..2366495 + 675 Protein_2170 PPE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2353482..2367806 14324


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15632.05 Da        Isoelectric Point: 7.4681

>T144800 WP_003905754.1 NZ_CP046728:c2361271-2360837 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T144800 NZ_CP062241:c3694646-3694539 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT144800 WP_003410814.1 NZ_CP046728:c2361532-2361278 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT144800 NZ_CP062241:3694695-3694761 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References