Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2223053..2223951 Replicon chromosome
Accession NZ_CP046728
Organism Mycobacterium tuberculosis strain TCDC11

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag GP477_RS10325 Protein ID WP_003410001.1
Coordinates 2223053..2223613 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag GP477_RS10330 Protein ID WP_003410003.1
Coordinates 2223610..2223951 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GP477_RS10295 2218222..2218875 - 654 WP_003409976.1 cutinase Cfp21 -
GP477_RS10300 2218990..2219220 + 231 WP_003409980.1 DUF167 domain-containing protein -
GP477_RS10305 2219305..2220216 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
GP477_RS10310 2220325..2220924 + 600 WP_003910883.1 L-lysine exporter -
GP477_RS10315 2221340..2221768 + 429 WP_003409992.1 cellulose-binding protein -
GP477_RS10320 2221994..2222533 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
GP477_RS10325 2223053..2223613 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
GP477_RS10330 2223610..2223951 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
GP477_RS10335 2224037..2224294 + 258 WP_003410006.1 hypothetical protein -
GP477_RS10340 2224195..2224530 - 336 WP_003410009.1 dehydrogenase -
GP477_RS10345 2224620..2224964 - 345 Protein_2044 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
GP477_RS10350 2224958..2225206 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
GP477_RS10355 2225306..2227621 - 2316 WP_003899120.1 cation transporter ATPase CptG -
GP477_RS10360 2227618..2227890 - 273 WP_003410017.1 DUF1490 family protein -
GP477_RS10365 2227943..2228299 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T144796 WP_003410001.1 NZ_CP046728:c2223613-2223053 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T144796 NZ_CP062241:c3034182-3033775 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT144796 WP_003410003.1 NZ_CP046728:c2223951-2223610 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT144796 NZ_CP062241:c3034429-3034163 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References