Detailed information of TA system TA144785

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1384449..1385137
• Replicon: chromosome
• Accession: NZ_CP046728
• Organism: Mycobacterium tuberculosis strain TCDC11

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: GP477_RS06520
• Protein ID: WP_003406304.1
• Coordinates: 1384706..1385137 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: GP477_RS06515
• Protein ID: WP_003406302.1
• Coordinates: 1384449..1384709 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GP477_RS06495	1380026..1380850	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
GP477_RS06500	1380855..1382036	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
GP477_RS06505	1382113..1383213	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
GP477_RS06510	1383384..1384373	+	990	WP_003406301.1	malate dehydrogenase	-
GP477_RS06515	1384449..1384709	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
GP477_RS06520	1384706..1385137	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
GP477_RS06525	1385160..1386743	-	1584	WP_009940130.1	PE family protein	-
GP477_RS06530	1386923..1387783	+	861	WP_003900301.1	hypothetical protein	-
GP477_RS06535	1387864..1388694	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
GP477_RS06540	1388751..1389044	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
GP477_RS06545	1389041..1389310	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T144785 WP_003406304.1 NZ_CP046728:1384706-1385137 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T144785 NZ_CP062241:c1408184-1407990 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT144785 WP_003406302.1 NZ_CP046728:1384449-1384709 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT144785 NZ_CP062241:1407813-1407991 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6