144784

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1238225..1238793 Replicon chromosome
Accession NZ_CP046728
Organism Mycobacterium tuberculosis strain TCDC11

Toxin (Protein)


Gene name vapC Uniprot ID G0TH08
Locus tag GP477_RS05865 Protein ID WP_003405865.1
Coordinates 1238419..1238793 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TH07
Locus tag GP477_RS05860 Protein ID WP_003405863.1
Coordinates 1238225..1238422 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GP477_RS05840 1234266..1234904 - 639 WP_003898730.1 lipid droplet-associated protein -
GP477_RS05845 1234994..1236001 + 1008 WP_003405853.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
GP477_RS05850 1236018..1237001 - 984 WP_003898731.1 hypothetical protein -
GP477_RS05855 1237064..1238137 + 1074 WP_003898732.1 redox-regulated ATPase YchF -
GP477_RS05860 1238225..1238422 + 198 WP_003405863.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GP477_RS05865 1238419..1238793 + 375 WP_003405865.1 type II toxin-antitoxin system VapC family toxin Toxin
GP477_RS05870 1238996..1239694 + 699 WP_003898733.1 hypothetical protein -
GP477_RS05875 1239812..1239997 + 186 WP_003901093.1 hypothetical protein -
GP477_RS05880 1239924..1240199 - 276 WP_003405867.1 hypothetical protein -
GP477_RS05885 1240442..1240765 + 324 WP_003405871.1 antibiotic biosynthesis monooxygenase -
GP477_RS05890 1240780..1241490 - 711 WP_003911399.1 hypothetical protein -
GP477_RS05895 1241512..1241721 + 210 WP_003911400.1 hypothetical protein -
GP477_RS05900 1241819..1242313 - 495 WP_003405876.1 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13444.56 Da        Isoelectric Point: 5.1881

>T144784 WP_003405865.1 NZ_CP046728:1238419-1238793 [Mycobacterium tuberculosis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Download         Length: 375 bp

>T144784 NZ_CP062241:c1265801-1265694 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6973.03 Da        Isoelectric Point: 11.7327

>AT144784 WP_003405863.1 NZ_CP046728:1238225-1238422 [Mycobacterium tuberculosis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Download         Length: 198 bp

>AT144784 NZ_CP062241:1265848-1265914 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TH08

Antitoxin

Source ID Structure
AlphaFold DB G0TH07

References