Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 751920..752553 Replicon chromosome
Accession NZ_CP046728
Organism Mycobacterium tuberculosis strain TCDC11

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag GP477_RS03445 Protein ID WP_003403365.1
Coordinates 751920..752303 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag GP477_RS03450 Protein ID WP_003403368.1
Coordinates 752398..752553 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GP477_RS03420 747212..747748 + 537 WP_003403341.1 50S ribosomal protein L10 -
GP477_RS03425 747785..748177 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
GP477_RS03430 748170..748865 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
GP477_RS03435 748936..750441 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
GP477_RS03440 750522..751532 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
GP477_RS03445 751920..752303 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
GP477_RS03450 752398..752553 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GP477_RS03455 752629..753345 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
GP477_RS03460 753621..753929 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
GP477_RS03465 753916..754161 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
GP477_RS03470 754271..754708 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
GP477_RS03475 754705..754959 - 255 WP_003911263.1 antitoxin VapB7 -
GP477_RS03480 755073..757436 + 2364 WP_003901895.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T144776 WP_003403365.1 NZ_CP046728:c752303-751920 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T144776 NZ_CP062240:c4525069-4524812 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT144776 WP_003403368.1 NZ_CP046728:c752553-752398 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT144776 NZ_CP062240:c4524800-4524255 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References