Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 709165..709790 Replicon chromosome
Accession NZ_CP046728
Organism Mycobacterium tuberculosis strain TCDC11

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag GP477_RS03225 Protein ID WP_003403218.1
Coordinates 709389..709790 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag GP477_RS03220 Protein ID WP_003403213.1
Coordinates 709165..709392 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GP477_RS03195 704344..704565 - 222 WP_003898525.1 DUF4926 domain-containing protein -
GP477_RS03200 704707..705312 + 606 WP_003898526.1 hypothetical protein -
GP477_RS03205 705331..707898 - 2568 WP_003901879.1 SEC-C domain-containing protein -
GP477_RS03210 707982..708731 + 750 WP_003898528.1 hypothetical protein -
GP477_RS03215 708728..708970 + 243 WP_003403210.1 hypothetical protein -
GP477_RS03220 709165..709392 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
GP477_RS03225 709389..709790 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
GP477_RS03230 709919..710614 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
GP477_RS03235 710611..711102 + 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
GP477_RS03240 711099..712190 + 1092 WP_003900977.1 galactokinase -
GP477_RS03245 712585..713649 + 1065 WP_003898532.1 hypothetical protein -
GP477_RS03250 713753..714700 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T144773 WP_003403218.1 NZ_CP046728:709389-709790 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T144773 NZ_CP062240:c3694646-3694539 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT144773 WP_003403213.1 NZ_CP046728:709165-709392 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT144773 NZ_CP062240:3694695-3694761 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References