Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 701627..702270 Replicon chromosome
Accession NZ_CP046728
Organism Mycobacterium tuberculosis strain TCDC11

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag GP477_RS03170 Protein ID WP_003403187.1
Coordinates 701869..702270 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag GP477_RS03165 Protein ID WP_003403184.1
Coordinates 701627..701872 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GP477_RS03130 696907..697377 - 471 WP_003403144.1 HAMP domain-containing protein -
GP477_RS03135 697421..698182 - 762 WP_003403148.1 two-component system response regulator TcrA -
GP477_RS03140 698239..698550 + 312 WP_003403164.1 hypothetical protein -
GP477_RS03145 698622..699572 + 951 WP_003900184.1 DUF1259 domain-containing protein -
GP477_RS03150 699813..700397 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
GP477_RS03155 700399..701109 + 711 Protein_625 transposase -
GP477_RS03160 701196..701582 + 387 WP_003403180.1 hypothetical protein -
GP477_RS03165 701627..701872 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GP477_RS03170 701869..702270 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
GP477_RS03175 702213..702440 + 228 WP_003900974.1 hypothetical protein -
GP477_RS03180 702658..702825 - 168 WP_077385191.1 DUF3800 domain-containing protein -
GP477_RS03185 702858..703055 - 198 WP_003403191.1 hypothetical protein -
GP477_RS03190 703135..704292 - 1158 WP_003898524.1 hypothetical protein -
GP477_RS03195 704344..704565 - 222 WP_003898525.1 DUF4926 domain-containing protein -
GP477_RS03200 704707..705312 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T144772 WP_003403187.1 NZ_CP046728:701869-702270 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T144772 NZ_CP062240:3270696-3271160 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT144772 WP_003403184.1 NZ_CP046728:701627-701872 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT144772 NZ_CP062240:3270361-3270696 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References